DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8642 and ANGPTL6

DIOPT Version :9

Sequence 1:	NP_610396.2	Gene:	CG8642 / 35845	FlyBaseID:	FBgn0033312	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	XP_011526650.1	Gene:	ANGPTL6 / 83854	HGNCID:	23140	Length:	537	Species:	Homo sapiens

Alignment Length:	210	Identity:	88/210 - (41%)
Similarity:	117/210 - (55%)	Gaps:	35/210 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 GIHLIHLPGFLPFLVPCEGQTAAGPGWTCIQRRLDGSVNFYRNWDAYSKGFGKLNGEFFIGLEKL 281
            |.|::.        |.||.|...| |||.||||.||||||:..|..|..|||:.:||:::|||.:
Human   346 GRHVVS--------VWCEQQLEGG-GWTVIQRRQDGSVNFFTTWQHYKAGFGRPDGEYWLGLEPV 401

  Fly   282 HRLTSSQPHELYISIRRFGGETSYAHYDDFLIGSEEEGYELKLLGHYQGNASDALRTHDKMKFST 346
            ::|||...|||.:.:..:||..:.||||.|.:..|.:.|.|: ||.|.|:|.|:|..|:...|||
Human   402 YQLTSRGDHELLVLLEDWGGRGARAHYDGFSLEPESDHYRLR-LGQYHGDAGDSLSWHNDKPFST 465

  Fly   347 YDRDNDAFTHMNCAEHHQGAWWYDFCSRSNLNG----------RYFKGEVDNPQSIYWEPWYSFR 401
            .|||.|:::. |||.:.:|.|||..|:.|||||          ||..|       :||.   .||
Human   466 VDRDRDSYSG-NCALYQRGGWWYHACAHSNLNGVWHHGGHYRSRYQDG-------VYWA---EFR 519

  Fly   402 ----SLKSVQMLIRP 412
                ||:...|||||
Human   520 GGAYSLRKAAMLIRP 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352
CG8642	NP_610396.2	FReD	213..413	CDD:238040	88/210 (42%)
ANGPTL6	XP_011526650.1	FReD	322..535	CDD:238040	88/210 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810