DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8642 and angptl1a

DIOPT Version :9

Sequence 1:	NP_610396.2	Gene:	CG8642 / 35845	FlyBaseID:	FBgn0033312	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001014820.1	Gene:	angptl1a / 544656	ZFINID:	ZDB-GENE-040724-269	Length:	480	Species:	Danio rerio

Alignment Length:	473	Identity:	134/473 - (28%)
Similarity:	215/473 - (45%)	Gaps:	87/473 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CLQVPSKIKSTT--------KAPVKEIPPTNGTQI-------GNVTAVAPVPEKLAEVHIDQHKT 67
            |:.:..|..|.|        :||..:....:.|.:       |.:.|.|..||.      |:.:.
Zfish    15 CISLLGKSHSGTELLHSRQRRAPADDSKKCSYTFLMPQQKITGPICASATGPEP------DKDRV 73

  Fly    68 IRISKGDLDDLL-----DVYM--------GKIAESAATIKDKENEINKLQTK--DQTGDELLRKF 117
            .|:...|:.::|     ::.|        |.:......::.:...:|...|:  .|...|::||.
Zfish    74 TRMDISDVREILSKQRREIEMLQLVADVDGNLVNEMKLLRKESRNMNSRVTQLYMQLLHEIIRKR 138

  Fly   118 ENLTQVCSAQQS--SFTTAIKEKDEQIKELEQKVKVYETRLKRKQHVLAEL--RKLNG------- 171
            :|..::...:..  :.||.:.....:.||||.:.......:..:..::|.|  |.|.|
Zfish   139 DNSLELAQLENRVLNVTTEMLRLASRYKELEMRFAGLAGTVNNQSVLIAALEERCLRGYGRQDLP 203

  Fly   172 SSALLIEHLKGKVVYFERKFRE--KKDD----------------------------LLADWEAAT 206
            :...|::.:...:.....:|..  ::|:                            |.||.....
Zfish   204 AVPPLVQVVPESIPANNNRFTNEIQRDNNNRAFPRGSRMDTPTPDPLGIPPPPQGTLTADGPFKD 268

  Fly   207 TSCV-PFGRS-PGIHLIHLPGFLPFLVP-CEGQTAAGPGWTCIQRRLDGSVNFYRNWDAYSKGFG 268
            .|.| ..|.| .|::|:...|....:.. ||.:...| |||..|||.||||||:|||:.|.||||
Zfish   269 CSQVRQAGHSTSGMYLLKAEGSDRLIQAWCEHKLDNG-GWTVFQRRKDGSVNFFRNWENYKKGFG 332

  Fly   269 KLNGEFFIGLEKLHRLTSSQPHELYISIRRFGGETSYAHYDDFLIGSEEEGYELKLLGHYQGNAS 333
            .::||.::|||.::.|.....::|.:.:..:.|:..||.|..|.:..|.||:.|: ||.|||||.
Zfish   333 NIDGEHWLGLENIYNLAKQGDYKLLVELEDWVGKKVYAEYSSFHLEPESEGFRLR-LGTYQGNAG 396

  Fly   334 DALRTHDKMKFSTYDRDNDAFTHMNCAEHHQGAWWYDFCSRSNLNGRYFKGEVDNPQ---SIYW- 394
            |:|.:|:...|:|.|||.||||. |||..|:|.|||:.|.::||||.::.|.|...:   .|:|
Zfish   397 DSLTSHNGKPFTTLDRDKDAFTG-NCAHFHKGGWWYNACGQTNLNGVWYSGGVYRSKFQDGIFWA 460

  Fly   395 EPWYSFRSLKSVQMLIRP 412
            |....:.|||||:|:|||
Zfish   461 EYGGGYYSLKSVRMMIRP 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	17/107 (16%)
CG8642	NP_610396.2	FReD	213..413	CDD:238040	90/206 (44%)
angptl1a	NP_001014820.1	FReD	264..479	CDD:238040	92/218 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810