DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8642 and tnr

DIOPT Version :9

Sequence 1:	NP_610396.2	Gene:	CG8642 / 35845	FlyBaseID:	FBgn0033312	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_919364.1	Gene:	tnr / 369191	ZFINID:	ZDB-GENE-030804-1	Length:	1350	Species:	Danio rerio

Alignment Length:	409	Identity:	127/409 - (31%)
Similarity:	181/409 - (44%)	Gaps:	95/409 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VPSKIKS----TTKAPVKEIPPTNGTQIGNVTAVAPVPEKLAEVHIDQHKTIRIS----KGDLDD 77
            :||...|    .||.|:     |:||.|.|.......|:.|....|: |::..||    ..|:|:
Zfish  1005 IPSTTYSVALYATKGPL-----TSGTVISNFVTPMDAPQNLTASEIN-HRSALISWQPPIADIDN 1063

  Fly    78 LLDVYMGKIAESAATIKDKENEINKLQTKDQTGD-----ELLRKFENLTQVCSAQQSSFTTAIKE 137
            .:..|..........|.|.|:...:|:...:|.:     ::.|..|....|    .:||||.
Zfish  1064 YMLTYKAADGSRKELILDAEDTWIRLEGLAETTEYTVRLQVARGLETSVIV----STSFTTG--- 1121

  Fly   138 KDEQIKELEQKVKVYETRLKRKQHVLAELRKLNGSSALLIEHLKG-KVVYFERKFREKKDDLLAD 201
                       .:::.|.....||:      |||      |.|.| ..:|..|       ||
Zfish  1122 -----------NRLFPTPQNCAQHL------LNG------ETLGGIYTIYVNR-------DL--- 1153

  Fly   202 WEAATTSCVPFGRSPGIHLIHLPGFLPFLVPCEGQTAAGPGWTCIQRRLDGSVNFYRNWDAYSKG 266
                         |.|:.           |.|: .|..|.||...|||.:|..:|.|.|..|..|
Zfish  1154 -------------SQGVQ-----------VYCD-MTTDGGGWIVFQRRQNGLTDFSRKWTDYKIG 1193

  Fly   267 FGKLNGEFFIGLEKLHRLTSSQPHELYISIRRFGGETSYAHYDDFLIGSEEEGYELKLLGHYQGN 331
            ||.|..||::||:.:|::.:...:||.|.::. |.|:.||:||.|.||..:..|:|: :|.|.|.
Zfish  1194 FGSLEDEFWLGLDNIHKIAAQGRYELRIDMKD-GQESVYANYDRFSIGDSKSLYKLR-IGEYSGT 1256

  Fly   332 ASDALRTHDKMKFSTYDRDND-AFTHMNCAEHHQGAWWYDFCSRSNLNGRYFKGEVDNPQSIYWE 395
            |.|:|..|....|||.|:||| |.|  |||..::|||||..|.|:||||:|  ||..:.|.|.|.
Zfish  1257 AGDSLSYHQSRPFSTKDKDNDIAVT--NCALSYKGAWWYKNCHRANLNGKY--GESRHSQGINWY 1317

  Fly   396 PW--YSFRSLKSVQMLIRP 412
            .|  :.| |:..|:|.:||
Zfish  1318 HWKGHEF-SIPFVEMKMRP 1335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	18/95 (19%)
CG8642	NP_610396.2	FReD	213..413	CDD:238040	82/203 (40%)
tnr	NP_919364.1	EGF_2	199..225	CDD:285248
		EB	234..283	CDD:279949
		EGF_2	294..318	CDD:285248
		fn3	323..401	CDD:278470
		fn3	411..490	CDD:278470
		fn3	500..579	CDD:278470
		FN3	590..674	CDD:238020
		fn3	682..754	CDD:278470
		fn3	771..849	CDD:278470
		FN3	859..935	CDD:214495
		fn3	949..1019	CDD:278470	4/13 (31%)
		fn3	1035..1103	CDD:278470	14/68 (21%)
		FReD	1126..1336	CDD:238040	95/264 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	1	1.100	-	-	LDO	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.810