Protein Alignment CG8642 and Angptl3

DIOPT Version :9

• Sequence 1: NP_610396.2
• Gene: CG8642 / 35845
• FlyBaseID: FBgn0033312
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_038941.1
• Gene: Angptl3 / 30924
• MGIID: 1353627
• Length: 455
• Species: Mus musculus
• Alignment Length: 470
• Identity: 123/470 - (26%)
• Similarity: 204/470 - (43%)
• Gaps: 79/470 - (16%)

  Fly     4 YSIILILIMLPSAWCLQVPSKIKSTTKAPVKEIPPTNGTQIGNVTAVAPVPEKLAEVHID-QHKT 67
            ::|.|.|.::|.....:|...:.|...||.:  |.:....:.:|..:|....:|.....| .|||
Mouse     2 HTIKLFLFVVPLVIASRVDPDLSSFDSAPSE--PKSRFAMLDDVKILANGLLQLGHGLKDFVHKT 64

  Fly    68 IRISKGDLDD------LLDVYMGKIAESAATIKDKENEINK----LQTKDQ----TGDELLRKFE 118
                ||.::|      :.|.....::.....||::|.|:.:    ||.|::    ...||..|.|
Mouse    65 ----KGQINDIFQKLNIFDQSFYDLSLRTNEIKEEEKELRRTTSTLQVKNEEVKNMSVELNSKLE 125

  Fly   119 NLTQVCSAQQ--------------------------SSFTTAIKEKDEQIKELEQKVKVYETRLK 157
            :|.:..:|.|                          :|..:.::::|..|:||.|.|:....:|.
Mouse   126 SLLEEKTALQHKVRALEEQLTNLILSPAGAQEHPEVTSLKSFVEQQDNSIRELLQSVEEQYKQLS 190

  Fly   158 RKQHVLAELRK---LNGSSALLIEHLKGK--------VVYFERKFREKKDDLLADWEAATTSCVP 211
            ::...:.|:.|   ..|........|..|        .:........::|||.||..|.
Mouse   191 QQHMQIKEIEKQLRKTGIQEPSENSLSSKSRAPRTTPPLQLNETENTEQDDLPADCSAV------ 249

  Fly   212 FGR---SPGIHLIHLPGFLPFLVPCEGQTAAGPGWTCIQRRLDGSVNFYRNWDAYSKGFGKLNGE 273
            :.|   :.|::.|.......|.|.|:  |.:|..||.||.|.|||.:|...|:.|.||||:|:||
Mouse   250 YNRGEHTSGVYTIKPRNSQGFNVYCD--TQSGSPWTLIQHRKDGSQDFNETWENYEKGFGRLDGE 312

  Fly   274 FFIGLEKLHRLTSSQPHELYISIRRFGGETSYAHYDDFLIGSEEEGYELKLLGHYQGNASDALRT 338
            |::||||::.:.....:.|.:.::.:.....|..| .|.:||.|..|.|. :....||...||..
Mouse   313 FWLGLEKIYAIVQQSNYILRLELQDWKDSKHYVEY-SFHLGSHETNYTLH-VAEIAGNIPGALPE 375

  Fly   339 HDKMKFSTYDRDNDAFTHMNCAEHHQGAWWY-DFCSRSNLNGRY----FKGEVDNPQSIYWEPW- 397
            |..:.|||:  ::.|...:.|.|.:.|.||: |.|..:||||:|    .|...:..:.|||.|.
Mouse   376 HTDLMFSTW--NHRAKGQLYCPESYSGGWWWNDICGENNLNGKYNKPRTKSRPERRRGIYWRPQS 438

  Fly   398 YSFRSLKSVQMLIRP 412
            ....::||.:|:::|
Mouse   439 RKLYAIKSSKMMLQP 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	26/130 (20%)
		FReD	213..413	CDD:238040	70/209 (33%)
Angptl3	NP_038941.1	Sufficient to inhibit LIPG/EL phospholipase activity. /evidence=ECO:0000250|UniProtKB:Q9Y5C1	17..207		40/195 (21%)
		Sufficient to inhibit LPL lipase activity. /evidence=ECO:0000250|UniProtKB:Q9Y5C1, ECO:0000269|PubMed:20581395	17..165		31/153 (20%)
		Required for inhibition of LPL lipase activity. /evidence=ECO:0000250|UniProtKB:Q9Y5C1	32..56		4/25 (16%)
		SPEC	<34..191	CDD:295325	33/160 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..242		4/39 (10%)
		FReD	241..453	CDD:238040	74/223 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810