DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8642 and Tnn

DIOPT Version :9

Sequence 1:	NP_610396.2	Gene:	CG8642 / 35845	FlyBaseID:	FBgn0033312	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001100659.2	Gene:	Tnn / 304913	RGDID:	1306002	Length:	1562	Species:	Rattus norvegicus

Alignment Length:	444	Identity:	125/444 - (28%)
Similarity:	194/444 - (43%)	Gaps:	99/444 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KSTTKAPVKEIPPTNGTQIGNVTAVAPVPEKLAEVHIDQHKTIRISKGDLDDLLDVYMGKIAESA 90
            |:.||||         |:|.:       |:.|....:.:: |..||...:...:|.||  :..::
  Rat  1138 KAKTKAP---------TEIDS-------PKNLVTNRVTEN-TATISWDPVRATIDRYM--VRYTS 1183

  Fly    91 ATIKDKENEINKLQTKDQTGDEL--LRKFENLTQVCSAQQSSFTTAIKEKDEQIKELEQ------ 147
            |..:.||..:    :|||:...|  |:.....|....||:.    |.:.|....|.|.:
  Rat  1184 ADGETKEVPV----SKDQSSTILTGLKPGMEYTIHVWAQKG----ARESKKADTKALTEIDPPKN 1240

  Fly   148 --------------------KVKVYETRLKRKQHVLAELRKLNGSSALLIEHLKGKVVY------ 186
                                ::..|....:....:|.|:....|.....::.|:..|.|
  Rat  1241 FRPFGVTHSSGVLTWMPPSAQIDGYILTYQLPNGILKEVELQRGQQRFELQDLEQGVTYPVSLVA 1305

  Fly   187 FERKFREKKDDLLADWEAATTSCVPFGRSP-----------------GIHLIHLPG--FLPFLVP 232
            |:...|.:        ..:||......|.|                 |::.|:|.|  ..|..|.
  Rat  1306 FKGNQRSR--------SVSTTLSTVDARFPHPSDCSQVQQNTNAAASGLYTIYLNGDASRPMQVY 1362

  Fly   233 CEGQTAAGPGWTCIQRRLDGSVNFYRNWDAYSKGFGKLNGEFFIGLEKLHRLT--SSQPHELYIS 295
            |:..|..| ||...|||..|.::|::.|.:|.:|||....||::||:|||.||  ::..:|:...
  Rat  1363 CDMDTDGG-GWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRAD 1426

  Fly   296 IRRFGGETSYAHYDDFLIGSEEEGYELKLLGHYQGNASDALRTHDKMKFSTYDRDNDAFTHMNCA 360
            ::. ..|::||.||.|.:.|.:|.|:|. :|.|:|.|.|||..|:..||:|:||||| ....|||
  Rat  1427 LQT-ANESAYAVYDFFQVASSKERYKLS-VGKYRGTAGDALTYHNGWKFTTFDRDND-IALSNCA 1488

  Fly   361 EHHQGAWWYDFCSRSNLNGRYFKGEVDNPQSIYWEPW--YSFRSLKSVQMLIRP 412
            ..|.|.|||..|..:|.||:|  ||..:.:.:.||||  :.| |:..|::.|||
  Rat  1489 LTHHGGWWYKNCHLANPNGKY--GETKHSEGVNWEPWKGHEF-SIPYVELKIRP 1539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	19/118 (16%)
CG8642	NP_610396.2	FReD	213..413	CDD:238040	84/223 (38%)
Tnn	NP_001100659.2	EGF_2	<142..166	CDD:285248
		EGF_2	169..197	CDD:285248
		EB	181..233	CDD:279949
		EGF_2	233..259	CDD:285248
		fn3	264..332	CDD:278470
		fn3	359..434	CDD:278470
		fn3	444..521	CDD:278470
		FN3	532..608	CDD:214495
		FN3	620..696	CDD:214495
		fn3	708..785	CDD:278470
		fn3	796..875	CDD:278470
		fn3	884..961	CDD:278470
		fn3	972..1049	CDD:278470
		FN3	1060..1136	CDD:214495
		FN3	1148..1224	CDD:214495	20/93 (22%)
		fn3	1236..1313	CDD:278470	9/76 (12%)
		FReD	1327..1540	CDD:238040	83/220 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm12326
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710