DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8642 and tncb

DIOPT Version :9

Sequence 1:	NP_610396.2	Gene:	CG8642 / 35845	FlyBaseID:	FBgn0033312	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001299845.1	Gene:	tncb / 30037	ZFINID:	ZDB-GENE-980526-104	Length:	1811	Species:	Danio rerio

Alignment Length:	384	Identity:	121/384 - (31%)
Similarity:	177/384 - (46%)	Gaps:	52/384 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 AVAPVPEKLAEVHIDQHKTIRISKGDLDDLLDVYMGKI------AESAATIKDKENEI----NKL 103
            :||||.|:::      ..|:......|.. ..:|..|:      |:||||..|...::    |..
Zfish  1447 SVAPVMERVS------GNTVEFEMSSLTP-ATLYTVKVYAFRDTAKSAATSTDFTTDVDAPQNLA 1504

  Fly   104 QTKDQTGDELLRKFENLTQVCSAQQSSFTTAIKEKDEQIKE--LEQKVKVYE-TRLKRKQHVLAE 165
            .:..||...:|     ..:...|..|.:..:.:..|..:||  |......|. ::|........:
Zfish  1505 ASNIQTETAML-----TWKPPRADISGYILSFESADGVVKEVVLSPTATFYSMSQLTASTEYTVK 1564

  Fly   166 LRKLNG---SSALLIEHLKGKVVYFERKFREKKDDLLADWEAATTSCVPFGRSPGIHLIHLPG-- 225
            |:.:.|   |..:....|...|:|     :..||...|.....|||        |::.|:|.|
Zfish  1565 LQAIAGPKRSRVISTVFLTIGVLY-----KHPKDCSQALLNGDTTS--------GLYTIYLRGDE 1616

  Fly   226 FLPFLVPCEGQTAAGPGWTCIQRRLDGSVNFYRNWDAYSKGFGKLNGEFFIGLEKLHRLTSSQPH 290
            ..|..|.|: .|..|.||....||..|.|.|:|||..|:.|||.||.||::||..||::||...:
Zfish  1617 SQPLQVYCD-MTTDGGGWIVFVRRQSGKVEFFRNWKNYTAGFGDLNDEFWLGLSNLHKITSFGQY 1680

  Fly   291 ELYISIRRFGGETSYAHYDDFLIGSEEEGYELKLLGHYQGNASDALRTHDKMKFSTYDRDND-AF 354
            ||.:.:|. .||::||.||.|.|......|::. :|.|.|.|.|::..|....|||||.||| |.
Zfish  1681 ELRVDLRD-KGESAYAQYDKFSISEPRARYKVH-VGGYSGTAGDSMTYHHGRPFSTYDNDNDIAV 1743

  Fly   355 THMNCAEHHQGAWWYDFCSRSNLNGRYFKGEVDNPQSIYWEPWYSF-RSLKSVQMLIRP 412
            |  |||..::||:||..|.|.|:.|||  |:..:.:.:.|..|... .|::..:|.|||
Zfish  1744 T--NCALSYKGAFWYKNCHRVNIMGRY--GDNSHSKGVNWFHWKGHEHSVEFAEMKIRP 1798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	21/103 (20%)
CG8642	NP_610396.2	FReD	213..413	CDD:238040	82/204 (40%)
tncb	NP_001299845.1	DnaJ	<471..>544	CDD:333066
		fn3	689..760	CDD:306538
		fn3	778..858	CDD:306538
		fn3	868..948	CDD:306538
		FN3	958..1047	CDD:238020
		fn3	1050..1128	CDD:306538
		fn3	1140..1215	CDD:306538
		fn3	1231..1303	CDD:306538
		fn3	1323..1400	CDD:306538
		fn3	1410..1482	CDD:306538	9/41 (22%)
		fn3	1498..1570	CDD:306538	13/76 (17%)
		FReD	1589..1798	CDD:238040	86/223 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.710