DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8642 and Angptl6

DIOPT Version :9

Sequence 1:	NP_610396.2	Gene:	CG8642 / 35845	FlyBaseID:	FBgn0033312	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_001100172.1	Gene:	Angptl6 / 298698	RGDID:	1311141	Length:	457	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	134/479 - (27%)
Similarity:	208/479 - (43%)	Gaps:	109/479 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LILIMLPSAW-CLQVPSKIKSTTKAPVKEIPPTNGTQIGNVTAVAPVPEKLAEVHIDQHKTIRIS 71
            |.|::|..|| .|...::.:.|.     .:.|...|.....::.|....:||        |:|:.
  Rat     9 LQLVLLLGAWKALGDAARCRVTL-----VLSPQMATSAVCRSSEASQDSELA--------TLRMR 60

  Fly    72 KGDLDDLLDVYMGKIAESAA------TIKDKENEIN------KLQTKDQTGDE---------LLR 115
            .|..::||.....:.||..|      .:::....:|      :.|.:.:.|.|         .|.
  Rat    61 LGRHEELLRALQRRAAEGGALAGEVRALREHSLTLNTRLGQLRAQLQQEAGAEPDLGAEPAAALG 125

  Fly   116 KFENLTQVCSAQQSSFTTAIKEKDEQIKELEQKVKVYETRLKRKQHVLAELRK------------ 168
            ..........|:....|..:::.:||::|..|.:..:.:.|.|.|...|...:
  Rat   126 LLAERALGAEAEARRTTARLQQLEEQLREHAQLMSQHSSLLGRLQRACASPERGQQQVLPLPLVP 190

  Fly   169 -----LNGSSA-------LLIEHLKGKVVYFERKFREKKDDLLADWEAATTSCVPFGR------- 214
                 |.||::       .:.||.:      |:..|:         :...:|.:|.|.
  Rat   191 LVPLSLVGSASNTSRRLDQIPEHQR------EQSLRQ---------QGPPSSPLPTGHVAVPTRP 240

  Fly   215 ----------------SPGIHLIHLPGFLPFLVPCEGQTAAGPGWTCIQRRLDGSVNFYRNWDAY 263
                            ..|::.:.| |.....|.||.|...| |||.||||.||||||:.||..|
  Rat   241 VGPWRDCAEAQGAGHWQSGVYELRL-GRRVVPVWCEQQQEGG-GWTVIQRRQDGSVNFFTNWQHY 303

  Fly   264 SKGFGKLNGEFFIGLEKLHRLTSSQPHELYISIRRFGGETSYAHYDDFLIGSEEEGYELKLLGHY 328
            ..|||:.:||:::|||.:|::||...|||.|.::.:||..:.||||.|.:..|.:.|.|: ||.|
  Rat   304 KVGFGRPDGEYWLGLEPVHQVTSRGDHELLILLKDWGGRGARAHYDSFSLEPESDHYRLR-LGQY 367

  Fly   329 QGNASDALRTHDKMKFSTYDRDNDAFTHMNCAEHHQGAWWYDFCSRSNLNGRYFKGEVDNPQSIY 393
            .|:|.|:|..|....|:|.|||.|:::. |||.:|:|.|||..|:.|||||.::.|  .:.:|.|
  Rat   368 HGDAGDSLSWHSDKPFNTVDRDRDSYSG-NCALYHRGGWWYHACAHSNLNGVWYHG--GHYRSRY 429

  Fly   394 WEP--WYSFR----SLKSVQMLIR 411
            .:.  |..||    |||...||.|
  Rat   430 QDGVYWAEFRGGAYSLKKAAMLTR 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	20/111 (18%)
CG8642	NP_610396.2	FReD	213..413	CDD:238040	90/228 (39%)
Angptl6	NP_001100172.1	Uso1_p115_C	66..>157	CDD:282695	15/90 (17%)
Angptl6	NP_001100172.1	FReD	242..453	CDD:238040	88/216 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810