Protein Alignment CG8642 and ANGPT2

DIOPT Version :10

• Sequence 1: NP_610396.2
• Gene: CG8642 / 35845
• FlyBaseID: FBgn0033312
• Length: 429
• Species: Drosophila melanogaster
• Sequence 2: NP_001138.1
• Gene: ANGPT2 / 285
• HGNCID: 485
• Length: 496
• Species: Homo sapiens
• Alignment Length: 433
• Identity: 126/433 - (29%)
• Similarity: 196/433 - (45%)
• Gaps: 69/433 - (15%)

  Fly    17 WCLQVPSKIKSTTKAPVKEIPPTNGTQIGNVTAV------------APVPEKLAEVHID-QHKTI 68
            |.:::.:.|:...|..:.|| ..|..|  |.|||            |....||.:|... .::|.
Human    93 WLMKLENYIQDNMKKEMVEI-QQNAVQ--NQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTT 154

  Fly    69 RISKGDLDDLLDVYMGKIAESAATIKDKENEINKLQTKDQTGDELLRKFEN----LTQVCSAQQS 129
            |:....|:..|..  .|:.:.   |.|:.:||||||.|:...::.:...|:    ..|....::.
Human   155 RLELQLLEHSLST--NKLEKQ---ILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKD 214

  Fly   130 SFTTAIKEKDEQIKELEQKV---KVYETRLKRKQHVLAE-----LRKLNGSSALLIEHLKGKVVY 186
            .....:.:::..|:|||:|:   .|..:.|:::||.|.|     |..::.|::
Human   215 QLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNS------------ 267

  Fly   187 FERKFREKKDDLLADWEAAT-TSCVPFGRS----PGIHLIHLPGFLPFLVPCEGQTAAGPGWTCI 246
                   .||..:|..|..: ..|....:|    .||:.:..|.....:.......|.|.|||.|
Human   268 -------AKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTII 325

  Fly   247 QRRLDGSVNFYRNWDAYSKGFGKLNGEFFIGLEKLHRLTSSQPHELYISIRRFGGETSYAHYDDF 311
            |||.||||:|.|.|..|..|||..:||:::|.|.:.:||:.|.:.|.|.::.:.|..:|:.|:.|
Human   326 QRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHF 390

  Fly   312 LIGSEEEGYELKLLGHYQGNA----SDALRTHDKMKFSTYDRDNDAFTHMNCAEHHQGAWWYDFC 372
            .:.|||..|.:.|.| ..|.|    |.:...:|   |||.|.|||... ..|::...|.||:|.|
Human   391 YLSSEELNYRIHLKG-LTGTAGKISSISQPGND---FSTKDGDNDKCI-CKCSQMLTGGWWFDAC 450

  Fly   373 SRSNLNGRYF--KGEVDNPQSIYWEPWY-SFRSLKSVQMLIRP 412
            ..|||||.|:  :...:....|.|..|. |..|||:..|:|||
Human   451 GPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRP 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	MAD	71..>198	CDD:461677	29/138 (21%)
		FReD	213..413	CDD:238040	77/211 (36%)
ANGPT2	NP_001138.1	CCDC158	<78..>295	CDD:464943	50/228 (22%)
		FBG	280..494	CDD:214548	78/219 (36%)