DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8642 and Tnr

DIOPT Version :9

Sequence 1:	NP_610396.2	Gene:	CG8642 / 35845	FlyBaseID:	FBgn0033312	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_037177.2	Gene:	Tnr / 25567	RGDID:	3886	Length:	1358	Species:	Rattus norvegicus

Alignment Length:	413	Identity:	128/413 - (30%)
Similarity:	187/413 - (45%)	Gaps:	58/413 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PSKIKSTTKAPVKEIPP-----TNGTQIGNVTAVAPVPE--KLAEVHIDQHKTIRI--SKGDLDD 77
            |::.....|||:.|:..     |:....|....|..|.|  :|.::....|.|:.:  :.|.|
  Rat   966 PTEALLQWKAPMGEVENYVIVLTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSGPL-- 1028

  Fly    78 LLDVYMGKIAESAATIKDKENEINKLQTKDQTGDELLRKFENLT-QVCSAQQSSFTTAIKEKDEQ 141
                ..|.||.:.:|:.|....:        |..|:.|:...:: |...|...::....|..|..
  Rat  1029 ----VSGTIATNFSTLLDPPANL--------TASEVTRQSALISWQPPRAAIENYVLTYKSTDGS 1081

  Fly   142 IKELEQKVKVYETRLKRKQH-----VLAELRKLNGSSAL--LIEHLKGKVVYFERKFREKKDDLL 199
            .|||....:....||:....     ||.:..:....|:|  .|....|:|      |...:|...
  Rat  1082 RKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTIFTTGGRV------FSHPQDCAQ 1140

  Fly   200 ADWEAATTSCVPFGRSPGIHLIHLPGFL--PFLVPCEGQTAAGPGWTCIQRRLDGSVNFYRNWDA 262
            ......|.|        |::.|.|.|.|  ...|.|: .|..|.||...|||.:|..:|:|.|..
  Rat  1141 HLMNGDTLS--------GVYTIFLNGELSHKLQVYCD-MTTDGGGWIVFQRRQNGQTDFFRKWAD 1196

  Fly   263 YSKGFGKLNGEFFIGLEKLHRLTSSQPHELYISIRRFGGETSYAHYDDFLIGSEEEGYELKLLGH 327
            |..|||.|..||::||:.:||:|:...:||.:.:|. |.|..:|:||.|.:......|:|: :|.
  Rat  1197 YRVGFGNLEDEFWLGLDNIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKLR-IGG 1259

  Fly   328 YQGNASDALRTHDKMKFSTYDRDND-AFTHMNCAEHHQGAWWYDFCSRSNLNGRYFKGEVDNPQS 391
            |.|.|.|:|..|....|||.||||| |.|  |||..::|||||..|.|:||||:|  ||..:.|.
  Rat  1260 YNGTAGDSLSYHQGRPFSTEDRDNDVAVT--NCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQG 1320

  Fly   392 IYWEPW--YSFRSLKSVQMLIRP 412
            |.|..|  :.| |:..|:|.:||
  Rat  1321 INWYHWKGHEF-SIPFVEMKMRP 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	19/96 (20%)
CG8642	NP_610396.2	FReD	213..413	CDD:238040	85/205 (41%)
Tnr	NP_037177.2	exchanger_TraA	<190..>328	CDD:411343
		EGF_Tenascin	203..231	CDD:376143
		fn3	328..398	CDD:394996
		fn3	416..496	CDD:394996
		fn3	507..586	CDD:394996
		FN3	595..679	CDD:238020
		fn3	687..766	CDD:394996
		fn3	776..855	CDD:394996
		fn3	865..944	CDD:394996
		fn3	954..1026	CDD:394996	13/59 (22%)
		FN3	1042..1127	CDD:238020	18/92 (20%)
		FReD	1134..1342	CDD:238040	86/223 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm12326
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	1	1.100	-	-	LDO	PTHR19143
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810