DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8642 and Tnr

DIOPT Version :9

Sequence 1:	NP_610396.2	Gene:	CG8642 / 35845	FlyBaseID:	FBgn0033312	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	NP_071707.2	Gene:	Tnr / 21960	MGIID:	99516	Length:	1358	Species:	Mus musculus

Alignment Length:	412	Identity:	125/412 - (30%)
Similarity:	185/412 - (44%)	Gaps:	56/412 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PSKIKSTTKAPVKEIPP-----TNGTQIGNVTAVAPVPE--KLAEVHIDQHKTIRI--SKGDLDD 77
            |::.....|||:.|:..     |:....|....|..|.|  :|.::....|.|:.:  :.|.|
Mouse   966 PTEALLQWKAPMGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSGPL-- 1028

  Fly    78 LLDVYMGKIAESAATIKDKENEINKLQTKDQTGDELLRKFENLT-QVCSAQQSSFTTAIKEKDEQ 141
                ..|.||.:.:|:.|..:.:        |..|:.|:...:: |...|...::....|..|..
Mouse  1029 ----MSGTIATNFSTLLDPPDNL--------TASEVTRQSALISWQPPRAAIENYVLTYKSTDGS 1081

  Fly   142 IKELEQKVKVYETRLKRKQH------VLAELRKLNGSSALLIEHLKGKVVYFERKFREKKDDLLA 200
            .|||....:....||:....      :|...::...||........|     .|.|...:|....
Mouse  1082 RKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTVFTTG-----GRVFSHPQDCAQH 1141

  Fly   201 DWEAATTSCVPFGRSPGIHLIHLPGFL--PFLVPCEGQTAAGPGWTCIQRRLDGSVNFYRNWDAY 263
            .....|.|        |::.|.|.|.|  ...|.|: .|..|.||...|||.:|..:|:|.|..|
Mouse  1142 LMNGDTLS--------GVYTIFLNGELSHKLQVYCD-MTTDGGGWIVFQRRQNGQTDFFRKWADY 1197

  Fly   264 SKGFGKLNGEFFIGLEKLHRLTSSQPHELYISIRRFGGETSYAHYDDFLIGSEEEGYELKLLGHY 328
            ..|||.|..||::||:.:||:|:...:||.:.:|. |.|..:|:||.|.:......|::: :|.|
Mouse  1198 RVGFGNLEDEFWLGLDNIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKIR-IGSY 1260

  Fly   329 QGNASDALRTHDKMKFSTYDRDND-AFTHMNCAEHHQGAWWYDFCSRSNLNGRYFKGEVDNPQSI 392
            .|.|.|:|..|....|||.||||| |.|  |||..::|||||..|.|:||||:|  ||..:.|.|
Mouse  1261 NGTAGDSLSYHQGRPFSTEDRDNDVAVT--NCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQGI 1321

  Fly   393 YWEPW--YSFRSLKSVQMLIRP 412
            .|..|  :.| |:..|:|.:||
Mouse  1322 NWYHWKGHEF-SIPFVEMKMRP 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	19/97 (20%)
CG8642	NP_610396.2	FReD	213..413	CDD:238040	84/205 (41%)
Tnr	NP_071707.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..58
		exchanger_TraA	<190..>328	CDD:411343
		EGF_Tenascin	203..231	CDD:376143
		fn3	328..398	CDD:394996
		fn3	416..496	CDD:394996
		fn3	507..586	CDD:394996
		FN3	595..679	CDD:238020
		fn3	687..766	CDD:394996
		fn3	776..855	CDD:394996
		fn3	865..944	CDD:394996
		fn3	954..1026	CDD:394996	13/59 (22%)
		FN3	1042..1127	CDD:238020	16/92 (17%)
		FBG	1134..1343	CDD:214548	87/225 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	1	1.100	-	-	LDO	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910