DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8642 and tnxb

DIOPT Version :9

Sequence 1:	NP_610396.2	Gene:	CG8642 / 35845	FlyBaseID:	FBgn0033312	Length:	429	Species:	Drosophila melanogaster
Sequence 2:	XP_031747219.1	Gene:	tnxb / 100489649	XenbaseID:	XB-GENE-481849	Length:	2840	Species:	Xenopus tropicalis

Alignment Length:	290	Identity:	102/290 - (35%)
Similarity:	147/290 - (50%)	Gaps:	40/290 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 DEQIKELEQKVKVYETRLKRKQHV---------LAELRKLNGSSALLIEHLKGKVVY-FERKFRE 193
            |.:||||.....:....|   .|:         |..||..:.|:.:......|::.| |.|...|
Frog  2568 DGEIKELILLANLSSFTL---SHLTPSTPYKVQLHALRGASSSAPISTSFTTGRIRYPFPRDCWE 2629

  Fly   194 K--KDDLLADWEAATTSCVPFGRSPGIHLIHLPGFL--PFLVPCEGQTAAGPGWTCIQRRLDGSV 254
            |  ..||                ..|:..|:|.|..  |.||.|:.:|..| ||...|||:||..
Frog  2630 KHMNGDL----------------QSGVFTIYLGGSKDDPLLVYCDMETDGG-GWIVFQRRIDGRT 2677

  Fly   255 NFYRNWDAYSKGFGKLNGEFFIGLEKLHRLTSSQPHELYISIRRFGGETSYAHYDDFLIGSEEEG 319
            :|:|||..|.:|||.|..||::|...||||:|..|:||.:.:|. |.|.:||.|:||.:..|::.
Frog  2678 DFWRNWRQYKEGFGNLTSEFWLGNIALHRLSSLAPYELRVDLRA-GAEAAYAVYEDFRVEGEDKH 2741

  Fly   320 YELKLLGHYQGNASDALRTHDKMKFSTYDRDNDAFTHMNCAEHHQGAWWYDFCSRSNLNGRYFKG 384
            :.|: :|.|:|||.|:|..|:.|.|||.|||.:. ..:.|:..::|||||..|..:||||.|  |
Frog  2742 FRLR-IGAYRGNAGDSLSYHNNMIFSTRDRDAEK-RILPCSISYRGAWWYKNCHYANLNGMY--G 2802

  Fly   385 EVDNPQSIYWEPWYSFR-SLKSVQMLIRPK 413
            ...:.|.:.|..|..|. |:...:|.:||:
Frog  2803 NNKDHQGVNWHTWKGFEFSIPFTEMKMRPQ 2832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8642	NP_610396.2	GluZincin	72..>163	CDD:301352	7/32 (22%)
CG8642	NP_610396.2	FReD	213..413	CDD:238040	82/202 (41%)
tnxb	XP_031747219.1	EGF_Tenascin	179..206	CDD:376143
		exchanger_TraA	<400..779	CDD:411343
		EGF_Tenascin	799..826	CDD:376143
		fn3	834..913	CDD:394996
		FN3	923..998	CDD:214495
		fn3	1790..1852	CDD:394996
		fn3	1881..1960	CDD:394996
		fn3	1972..2051	CDD:394996
		fn3	2064..2141	CDD:394996
		fn3	2170..2245	CDD:394996
		fn3	2267..2338	CDD:394996
		FN3	2356..2433	CDD:238020
		fn3	2445..2522	CDD:394996
		fn3	2531..2609	CDD:394996	11/43 (26%)
		FReD	2622..2831	CDD:238040	87/230 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000029
OrthoInspector	1	1.000	-	-		mtm14088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910