DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rgr and ZKSCAN3

DIOPT Version :9

Sequence 1:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001229823.1	Gene:	ZKSCAN3 / 80317	HGNCID:	13853	Length:	538	Species:	Homo sapiens

Alignment Length:	608	Identity:	143/608 - (23%)
Similarity:	212/608 - (34%)	Gaps:	179/608 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 PRHPDYKYNAKRS-----AYGDLAGPLESICHRQLSGAEIFAVLKELRCRYRRELKKVNALGGKY 407
            |..||......|.     .|.:.|||.|::..           |:|| ||.
Human    35 PSSPDLGSEGSRERFRGFRYPEAAGPREALSR-----------LREL-CRQ-------------- 73

  Fly   408 KSRLWYFERMDFLRCVIENRRAEREAKISNESTES---EKSCETDADSCGKSSLYHEVLSFILDA 469
                |....|.....::|....|:...|...:.:|   |:..|:.           |.:..:|:.
Human    74 ----WLQPEMHSKEQILELLVLEQFLTILPGNLQSWVREQHPESG-----------EEVVVLLEY 123

  Fly   470 FKRQECLWNPQ-----HYDYTTCCKTELF------RDISVQLQEE-LNYELSGEE---------- 512
            .:||.....||     ......|||..|.      :....||.:. |.:|..|.:
Human   124 LERQLDEPAPQVSGVDQGQELLCCKMALLTPAPGSQSSQFQLMKALLKHESVGSQPLQDRVLQVP 188

  Fly   513 ------CCNEIQKLRTRYRKELRMVIKHKGLYLPKLWCYDEMEFLQPILQEQIFNKISKKIGVVG 571
                  ||.|.:.:.:|...|.:.::|.:.:.|.          |.|...:|
Human   189 VLAHGGCCREDKVVASRLTPESQGLLKVEDVALT----------LTPEWTQQ------------- 230

  Fly   572 SNQKTKFIDASSIRFDNTEKQLQFVEIYHNYSALWDVDHPDFRSNTYRSQALGQMLDEINTTFHT 636
                    |:|.......|||       .|:.:|               .:||   ||..|....
Human   231 --------DSSQGNLCRDEKQ-------ENHGSL---------------VSLG---DEKQTKSRD 262

  Fly   637 SYTAEQLE-----KTLFNLRKEFSAQKRKILTESEDSSSIPLLHAKLAEFLDQNLGPFRCDICSD 696
            ...||:|.     |...:||::.:    :|.|.:|.......|..|     .:|....|..||.:
Human   263 LPPAEELPEKEHGKISCHLREDIA----QIPTCAEAGEQEGRLQRK-----QKNATGGRRHICHE 318

  Fly   697 LVKTCDQ---YKVHRSAHDGTQPFICTLCGKGFQMPCNLTVHIRRHRRDFPYSCEQCDKRFATST 758
            ..|:..|   ...||..|.|.:|:.|..|||.|.....|.:|.|.|..:.||.||:|.|.|:.|:
Human   319 CGKSFAQSSGLSKHRRIHTGEKPYECEECGKAFIGSSALVIHQRVHTGEKPYECEECGKAFSHSS 383

  Fly   759 EVAIHLRTHTGERPYICDLCGKSFKTWSFFDIHRRRHLNQSTFHCPICAKGFYEKNRFTDHMNSH 823
            ::..|.||||||:||.||.|||:|........|.|.|..:..:.|.:|.|.|...:....|...|
Human   384 DLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHRIHTGEKPYQCSMCGKAFRRSSHLLRHQRIH 448

  Fly   824 --------------WAIR------------KHLCTVCGKTFTTYGNLKKHTELHLAVKKYKCGTC 862
                          |..|            .:.|..|.::||....|.:|.::|...|.|:|..|
Human   449 TGDKNVQEPEQGEAWKSRMESQLENVETPMSYKCNECERSFTQNTGLIEHQKIHTGEKPYQCNAC 513

  Fly   863 GKRFAQFASLRWHKKREHSSVGQ 885
            ||.|.:.:.|..|::   |.||:
Human   514 GKGFTRISYLVQHQR---SHVGK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510	16/76 (21%)
		MADF_DNA_bdg	465..551	CDD:287510	21/113 (19%)
		MADF_DNA_bdg	595..682	CDD:287510	18/91 (20%)
		C2H2 Zn finger	691..711	CDD:275368	6/22 (27%)
		C2H2 Zn finger	719..739	CDD:275368	8/19 (42%)
		zf-H2C2_2	731..756	CDD:290200	11/24 (46%)
		COG5048	742..>824	CDD:227381	32/95 (34%)
		C2H2 Zn finger	747..767	CDD:275368	8/19 (42%)
		zf-H2C2_2	763..784	CDD:290200	15/20 (75%)
		C2H2 Zn finger	775..795	CDD:275368	8/19 (42%)
		C2H2 Zn finger	803..818	CDD:275368	4/14 (29%)
		C2H2 Zn finger	831..851	CDD:275368	6/19 (32%)
		C2H2 Zn finger	859..877	CDD:275368	7/17 (41%)
ZKSCAN3	NP_001229823.1	SCAN	42..154	CDD:128708	29/152 (19%)
		SCAN	42..130	CDD:280241	23/128 (18%)
		KRAB	214..274	CDD:214630	20/115 (17%)
		KRAB	217..252	CDD:279668	11/87 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..274		16/93 (17%)
		zf-C2H2	314..336	CDD:278523	6/21 (29%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		zf-H2C2_2	329..351	CDD:290200	9/21 (43%)
		C2H2 Zn finger	344..364	CDD:275368	8/19 (42%)
		zf-H2C2_2	356..381	CDD:290200	11/24 (46%)
		COG5048	<368..515	CDD:227381	45/146 (31%)
		C2H2 Zn finger	372..392	CDD:275368	8/19 (42%)
		zf-H2C2_2	384..409	CDD:290200	15/24 (63%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		zf-H2C2_2	412..437	CDD:290200	7/24 (29%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		zf-C2H2	480..502	CDD:278523	6/21 (29%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		zf-H2C2_2	495..519	CDD:290200	10/23 (43%)
		C2H2 Zn finger	510..530	CDD:275368	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910