DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rgr and ZNF711

DIOPT Version :9

Sequence 1:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	XP_011529321.1	Gene:	ZNF711 / 7552	HGNCID:	13128	Length:	811	Species:	Homo sapiens

Alignment Length:	563	Identity:	119/563 - (21%)
Similarity:	195/563 - (34%)	Gaps:	171/563 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   423 VIENRRAEREAKI-----SNESTESEKSCETDADSCGKSSLYHEVL-----SFILDAFKRQE--- 474
            |::..|.:||..:     .:...|.:.||...||     .:|.||:     ...|...:.::
Human   283 VLDQSRMQREKMVYMAVKDSSQEEDDISCAEIAD-----EVYMEVIVGEEEGTSLPEIQLEDSDV 342

  Fly   475 ------CLWNPQHYD-------YTTCCKTELFRDISVQLQEELNYELSGEECCNEI-------QK 519
                  .:|...:.|       |..|..:....|.:::.:.....:..  :.|:.|       ||
Human   343 NKTVVPVVWAAAYGDERRVSRRYEDCQASGNTLDSALESRSSTAAQYL--QICDGINTNKVLKQK 405

  Fly   520 LRTRYRKELR-----MVIKHKGLYLPKLWCYDEMEFLQPILQEQIFNKISKKIGVVGSNQKT--- 576
            .:.|.|.|.|     ::|...|..|....|:             |..|..|..|.:..:.|.
Human   406 AKKRRRGETRQWQTAVIIGPDGQPLTVYPCH-------------ICTKKFKSRGFLKRHMKNHPD 457

  Fly   577 ----KFIDASSIRFDNTEKQLQFVEIYHNYSALWDVDHPDFRSNTYRSQALGQMLDEINTTFH-T 636
                |....:...| .|.|::.|    ||:          ..|:        :::::::.|.. |
Human   458 HLMRKKYQCTDCDF-TTNKKVSF----HNH----------LESH--------KLINKVDKTHEFT 499

  Fly   637 SYTAEQLEKTLFNLRKEFSAQKRKILTESEDSSSIPLLHAKLAEFLDQNLGPFRCDICSDLVKTC 701
            .||....|.:..:..|       .||.:.|     |.:|              :|..|.  .:|.
Human   500 EYTRRYREASPLSSNK-------LILRDKE-----PKMH--------------KCKYCD--YETA 536

  Fly   702 DQYKVHR---SAHDGTQPFICTLCGKGFQMPCNLTVHIRRHRRDFPYSCEQCDKRFATSTEVAIH 763
            :|..::|   :.|....|.:|..|||||:.|..|..|:|.|..:.||.|:.|..|.|..:.:..|
Human   537 EQGLLNRHLLAVHSKNFPHVCVECGKGFRHPSELKKHMRTHTGEKPYQCQYCIFRCADQSNLKTH 601

  Fly   764 LRT-HTGERPYICDLCGKSFKTWSFFDIHRRRHLN----QSTFHCPICAKGFYEKNRFTDHMNS- 822
            ::: |....||.|:.|.::|..    :...:|||:    ..|..||.|.......:....|:.|
Human   602 IKSKHGNNLPYKCEHCPQAFGD----ERELQRHLDLFQGHKTHQCPHCDHKSTNSSDLKRHIISV 662

  Fly   823 HWAIRKHLCTVCGKTFTTYGNLKKHTELHLAVKKY-----------------------------K 858
            |.....|.|.||.|.|.....||||:::|...|.:                             |
Human   663 HTKDFPHKCEVCDKGFHRPSELKKHSDIHKGRKIHQCRHCDFKTSDPFILSGHILSVHTKDQPLK 727

  Fly   859 CGTCGKRFAQFASLRWHKKR------------EHSSVGQAGGK 889
            |..|.:.|.|...|:.|.|.            |:|:...:|.|
Human   728 CKRCKRGFRQQNELKKHMKTHTGRKIYQCEYCEYSTTDASGFK 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510
		MADF_DNA_bdg	465..551	CDD:287510	18/113 (16%)
		MADF_DNA_bdg	595..682	CDD:287510	15/87 (17%)
		C2H2 Zn finger	691..711	CDD:275368	5/22 (23%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		zf-H2C2_2	731..756	CDD:290200	9/24 (38%)
		COG5048	742..>824	CDD:227381	22/87 (25%)
		C2H2 Zn finger	747..767	CDD:275368	5/20 (25%)
		zf-H2C2_2	763..784	CDD:290200	7/21 (33%)
		C2H2 Zn finger	775..795	CDD:275368	3/19 (16%)
		C2H2 Zn finger	803..818	CDD:275368	3/14 (21%)
		C2H2 Zn finger	831..851	CDD:275368	9/19 (47%)
		C2H2 Zn finger	859..877	CDD:275368	6/17 (35%)
ZNF711	XP_011529321.1	Zfx_Zfy_act	69..418	CDD:282547	26/141 (18%)
		COG5048	<426..604	CDD:227381	52/241 (22%)
		zf-C2H2	433..455	CDD:278523	6/34 (18%)
		C2H2 Zn finger	435..455	CDD:275368	6/32 (19%)
		C2H2 Zn finger	528..549	CDD:275368	5/22 (23%)
		COG5048	550..>807	CDD:227381	59/225 (26%)
		zf-C2H2	555..577	CDD:278523	10/21 (48%)
		C2H2 Zn finger	557..577	CDD:275368	10/19 (53%)
		zf-H2C2_2	569..593	CDD:290200	9/23 (39%)
		C2H2 Zn finger	585..606	CDD:275368	5/20 (25%)
		C2H2 Zn finger	614..640	CDD:275368	6/29 (21%)
		C2H2 Zn finger	642..663	CDD:275368	5/20 (25%)
		C2H2 Zn finger	671..720	CDD:275368	11/48 (23%)
		C2H2 Zn finger	728..748	CDD:275368	7/19 (37%)
		zf-H2C2_2	740..764	CDD:290200	5/23 (22%)
		C2H2 Zn finger	756..777	CDD:275368	4/15 (27%)
		C2H2 Zn finger	785..805	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000