DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rgr and Phs

DIOPT Version :9

Sequence 1:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_648789.3	Gene:	Phs / 39697	FlyBaseID:	FBgn0036522	Length:	971	Species:	Drosophila melanogaster

Alignment Length:	888	Identity:	181/888 - (20%)
Similarity:	300/888 - (33%)	Gaps:	249/888 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 FGFNCAFCPAICLQFSVFMDHIRVQHTQDVSR-RYETE---EERCPQTDLVIMELDCPEIYPPEA 95
            |.::|..|........:...|.:::|.:...| |.:|:   ||......|:|..|:..::.|
  Fly   156 FIYSCTSCTHHYDDNLILSRHFQLEHVEKSKRKRGKTKAAAEEPMVTPPLIIDPLEMGQLKP--- 217

  Fly    96 PRKCSWEADMDIQLMSLVPSPPAVHIAPLPPPKTTETPEIDLVYVVEN---------PLPPSPPP 151
               |:       ||  ||.....:.:.     ....:..:|:|...|:         .|.|...|
  Fly   218 ---CA-------QL--LVQGESVLQLC-----LACNSQFVDVVRFQEHLSQQHGYFQLLVPKEEP 265

  Fly   152 SADISVDELPGSSPQSFDLDPFAVLHEVVTMTPPTPIA----------PPPGPPTPNPTPTATPA 206
            :                ||.|    |.:||:  |..:|          |.|.|.||.|......|
  Fly   266 T----------------DLPP----HAMVTI--PGALALNKANAQLQLPIPAPETPPPEQDGKEA 308

  Fly   207 PLPRYETRRVRQRLCTISSTTINPGQDRLAGQRLSRREPNTGNAMQRKL-----RQSQNEQPKDG 266
            |.......:.       ..|.||.....:|.:|:.:...:..|.|..||     |..:..:|
  Fly   309 PPSNASNDKE-------DLTMINDMVAVIAAERVKKTSSSKVNKMIIKLPMPKKRGRKRTKP--- 363

  Fly   267 AVDEVAVEEHKGTEPTGQPEK-SAMELTPPATPPTPLPPTSPTSSTASCADFQSKSRRELERNHE 330
               |...:|....|.|.:.:| :..|...|...|.   ....||:.|.....||.:..::::|.:
  Fly   364 ---ESLRDEQDNAEKTDKKKKLNKEEGQQPVLEPL---QAKKTSNQAENGATQSNNVVKVQQNAK 422

  Fly   331 FVGCLLREYERTEKL-WNPRH-PDYKYNAKRSAYGDLAGPLESICHRQLSGAEIFAVLKELRCRY 393
              |......:..:|. .||:| .:.:.|:|.:.  :.....|:|..:||:..|
  Fly   423 --GSKKDGTQSAQKSETNPKHLENAETNSKDNT--ESVALKETIHDKQLTIDE------------ 471

  Fly   394 RRELKKVNALGGKYKSRLWYFERMDFLRCVIENRRAEREAKISNESTESEKSCETDADSCGKSSL 458
                      .||                          |....:...::|..:....:.|||.:
  Fly   472 ----------AGK--------------------------AGTQKDDNSNQKQLDKSEANAGKSKM 500

  Fly   459 YHEVLSFILDAFKRQECLWNPQHYDYTTCCKTELFRDISVQLQEELNYELSGEECCNEIQKLRTR 523
            ..:|                  |.              .:.::...:::...||..|..:  |.|
  Fly   501 VDQV------------------HQ--------------QMPVESAKDHQQMTEEPTNSTK--RKR 531

  Fly   524 YRKELRMVIKHKGLYLPKLWCYDEMEFL-QPILQEQIFNKISKKIGVVGSNQKTKFIDASSIRFD 587
            .|||.:..       .|.|....:.|.. :|.|.|:...|         |.|...::    :...
  Fly   532 GRKERKSP-------TPVLIPLGDKEIKEEPELPERRMRK---------SRQHVDYV----VEIK 576

  Fly   588 NTEKQLQFVEIYHNYSALWDVDHPDFRSNTYRSQALGQMLDEINTTF--HTSYTAEQLEKTLFNL 650
            :.|:....||..       :||                  |:.:.|.  |.|.|.|
  Fly   577 DEEEDDDEVEEA-------EVD------------------DDSSATISPHNSSTDE--------- 607

  Fly   651 RKEFSAQKRKILTESEDSSSIPLLHAKLAEFLDQNLGPFRCDICSDLVKTCDQYKVHRSAHDGTQ 715
              .|::.||:...||: .:.|..:|.              |:.|....|...:.:.|...|.|.:
  Fly   608 --SFTSIKRESSEESQ-HNGIGGIHT--------------CNFCGKTFKRFSRMQDHLRLHTGEK 655

  Fly   716 PFICTLCGKGFQMPCNLTVHIRRHRRDFPYSCEQCDKRFATSTEVAIHLRTHTGERPYICDLCGK 780
            |::|..||:.|::...|..|..|||.:..|.|:.|....||..::::|:|.|..:|.|.||.|.|
  Fly   656 PYVCGQCGRAFRLKMRLVEHQLRHRAEKAYKCDICSMPLATKQDLSLHMRHHKNDRRYKCDKCNK 720

  Fly   781 SFKTWSFFDIHRRRHLNQSTFHCPICAKGFYEKNRFTDHMNSHWAIRKHLCTVCGKTFTTYGNLK 845
            .|...|...||.|.|..:..:.|.:|.|.|..:.....|..:|...:...|.:|.|.|....:::
  Fly   721 GFVRSSDLSIHVRIHTGEKPYSCDLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDMR 785

  Fly   846 KHTELHLAVKKYKCGTCGKRFAQFASLRWHKKREHSSVGQAGG 888
            .|...|...|.|.|..|.:.::...:|..|::|||....|..|
  Fly   786 VHMRRHTGEKPYNCDACQRGYSSRVNLLRHQEREHGIEEQVPG 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510	13/86 (15%)
		MADF_DNA_bdg	465..551	CDD:287510	12/85 (14%)
		MADF_DNA_bdg	595..682	CDD:287510	17/88 (19%)
		C2H2 Zn finger	691..711	CDD:275368	4/19 (21%)
		C2H2 Zn finger	719..739	CDD:275368	6/19 (32%)
		zf-H2C2_2	731..756	CDD:290200	8/24 (33%)
		COG5048	742..>824	CDD:227381	25/81 (31%)
		C2H2 Zn finger	747..767	CDD:275368	6/19 (32%)
		zf-H2C2_2	763..784	CDD:290200	10/20 (50%)
		C2H2 Zn finger	775..795	CDD:275368	9/19 (47%)
		C2H2 Zn finger	803..818	CDD:275368	4/14 (29%)
		C2H2 Zn finger	831..851	CDD:275368	5/19 (26%)
		C2H2 Zn finger	859..877	CDD:275368	4/17 (24%)
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	58/218 (27%)
		C2H2 Zn finger	631..651	CDD:275368	4/19 (21%)
		zf-H2C2_2	644..666	CDD:290200	7/21 (33%)
		zf-H2C2_2	699..724	CDD:290200	10/24 (42%)
		zf-C2H2	713..735	CDD:278523	10/21 (48%)
		C2H2 Zn finger	715..735	CDD:275368	9/19 (47%)
		zf-H2C2_2	727..750	CDD:290200	7/22 (32%)
		C2H2 Zn finger	743..763	CDD:275368	5/19 (26%)
		zf-H2C2_2	755..780	CDD:290200	6/24 (25%)
		C2H2 Zn finger	771..791	CDD:275368	5/19 (26%)
		zf-H2C2_2	783..808	CDD:290200	6/24 (25%)
		C2H2 Zn finger	799..816	CDD:275370	3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3304
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.860