DRSC/TRiP Functional Genomics Resources

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Protein Alignment rgr and ZNF793

DIOPT Version :10

Sequence 1:NP_001163089.2 Gene:rgr / 35843 FlyBaseID:FBgn0267792 Length:889 Species:Drosophila melanogaster
Sequence 2:NP_001013681.2 Gene:ZNF793 / 390927 HGNCID:33115 Length:406 Species:Homo sapiens


Alignment Length:401 Identity:99/401 - (24%)
Similarity:161/401 - (40%) Gaps:70/401 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   492 LFRDISVQLQEEL---NYE---------LSGEE-------------CCNEIQKLRTRYRKELRMV 531
            |:||:.::....|   .||         |..||             |..:|.::..:.::...|:
Human    32 LYRDVMLETYSNLVSVGYEGTKPDVILRLEQEEAPWIGEAACPGCHCWEDIWRVNIQRKRRQDML 96

  Fly   532 IKHKGLY----LPKLWCYDEMEFLQ-PILQEQIFNKISKKIGVVGSNQKTKFIDASSIRFDNTEK 591
            ::.....    |||....:..:|.: .:|...:|:.|.                 |...::...|
Human    97 LRPGAAISKKTLPKEKSCEYNKFGKISLLSTDLFSSIQ-----------------SPSNWNPCGK 144

  Fly   592 QLQFVEIYHNYSALWDVDHPDFRSNTYRSQ----ALGQMLDEINTTFHTSYTAEQLEKTLFNLRK 652
            .|.     ||      :|...|:.|..:.|    |.|::|..||   |......:..:...:..|
Human   145 NLN-----HN------LDLIGFKRNCAKKQDECYAYGKLLQRIN---HGRRPNGEKPRGCSHCEK 195

  Fly   653 EFSAQKRKILTESEDSSSIPLLHAKLAEFLDQNLGPFRCDICSDLVKTCDQYKVHRSAHDGTQPF 717
            .|: |...::.:...|.|  ||:.:  :.:.....|..|..|........::..|:.:|.|.:|:
Human   196 AFT-QNPALMYKPAVSDS--LLYKR--KRVPPTEKPHVCSECGKAFCYKSEFIRHQRSHTGEKPY 255

  Fly   718 ICTLCGKGFQMPCNLTVHIRRHRRDFPYSCEQCDKRFATSTEVAIHLRTHTGERPYICDLCGKSF 782
            .||.|||.|.....|..|.|.|....|:.|..|.|.|...:....|.||||||||::|..|||||
Human   256 GCTDCGKAFSHKSTLIKHQRIHTGVRPFECFFCGKAFTQKSHRTEHQRTHTGERPFVCSECGKSF 320

  Fly   783 KTWSFFDIHRRRHLNQSTFHCPICAKGFYEKNRFTDHMNSHWAIRKHLCTVCGKTFTTYGNLKKH 847
            ...|:.::||:.|..:..:.|..|.|.|.:|:....|..:|...:.:.|..|||.|....||.:|
Human   321 GEKSYLNVHRKMHTGERPYRCRECGKSFSQKSCLNKHWRTHTGEKPYGCNECGKAFYQKPNLSRH 385

  Fly   848 TELHLAVKKYK 858
            .::|.....|:
Human   386 QKIHARKNAYR 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rgrNP_001163089.2 MADF 334..425 CDD:214738
MADF 466..556 CDD:214738 16/93 (17%)
MADF_DNA_bdg 595..682 CDD:463144 19/90 (21%)
C2H2 Zn finger 691..711 CDD:275368 3/19 (16%)
C2H2 Zn finger 719..739 CDD:275368 9/19 (47%)
COG5048 742..>824 CDD:227381 30/81 (37%)
C2H2 Zn finger 747..767 CDD:275368 6/19 (32%)
C2H2 Zn finger 775..795 CDD:275368 9/19 (47%)
C2H2 Zn finger 803..818 CDD:275368 5/14 (36%)
C2H2 Zn finger 831..851 CDD:275368 8/19 (42%)
C2H2 Zn finger 859..877 CDD:275368 99/401 (25%)
ZNF793NP_001013681.2 KRAB 8..68 CDD:214630 9/35 (26%)
C2H2 Zn finger 190..221 CDD:275368 7/35 (20%)
COG5048 <225..385 CDD:227381 55/159 (35%)
C2H2 Zn finger 229..249 CDD:275368 3/19 (16%)
C2H2 Zn finger 257..277 CDD:275368 9/19 (47%)
C2H2 Zn finger 285..305 CDD:275368 6/19 (32%)
C2H2 Zn finger 313..333 CDD:275368 9/19 (47%)
C2H2 Zn finger 341..361 CDD:275368 6/19 (32%)
C2H2 Zn finger 369..389 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

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