DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rgr and MTF-1

DIOPT Version :9

Sequence 1:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster

Alignment Length:	316	Identity:	81/316 - (25%)
Similarity:	123/316 - (38%)	Gaps:	65/316 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   582 SSIRFDNTEKQLQFVEIYHNYSALWDVDHPDFRSNTYRSQALGQMLDEINTTFHTSYTAEQLEKT 646
            :||..|:|.....:..|..:|...:|.:.||      ..:.|...:..  ...|.....|::|:
  Fly   252 NSISRDSTSNSPAYFTIETSYVDEYDPNEPD------EDEQLAHCIQP--GVLHQDVDEEEVER- 307

  Fly   647 LFNLRKEFSAQKRKILTESEDSSSIPLLHAKLAEFLDQNLGPFRCDICSDLVKTCDQYKVHRSAH 711
                             :.|:...:.|.:    |..|:.|..:||:..:
  Fly   308 -----------------QDENDQLMALAY----ESSDEALSRYRCNYEN---------------- 335

  Fly   712 DGTQPFICTLCGKGFQMPCNLTVHIRRHRRDFPYSCEQ--CDKRFATSTEVAIHLRTHTGERPYI 774
                      |.:.:....||..|::.|..|:.:.|.:  |.|.|.||..:.||:|.||..:||.
  Fly   336 ----------CYRSYSTIGNLRTHLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYE 390

  Fly   775 CDL--CGKSFKTWSFFDIHRRRHLNQSTFHCPICAKGFYEKNRFTDHMNSHWAIRKHLCTV--CG 835
            |::  |.|:|.|......|.|.| |..||:|.:|.|.|...:....||.:|...|.:.|..  ||
  Fly   391 CEVSGCDKAFNTRYRLHAHLRLH-NGETFNCELCQKCFTTLSDLKKHMRTHTQERPYKCPEDDCG 454

  Fly   836 KTFTTYGNLKKHTELHLAVKKYKC--GTCGKRFAQFASLRWHKKREHSSVGQAGGK 889
            |.||...:||.|...|...|.|.|  .:|.|.|:...||:.|||.....:...|.|
  Fly   455 KAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510
		MADF_DNA_bdg	465..551	CDD:287510
		MADF_DNA_bdg	595..682	CDD:287510	12/86 (14%)
		C2H2 Zn finger	691..711	CDD:275368	1/19 (5%)
		C2H2 Zn finger	719..739	CDD:275368	4/19 (21%)
		zf-H2C2_2	731..756	CDD:290200	9/26 (35%)
		COG5048	742..>824	CDD:227381	31/85 (36%)
		C2H2 Zn finger	747..767	CDD:275368	9/21 (43%)
		zf-H2C2_2	763..784	CDD:290200	10/22 (45%)
		C2H2 Zn finger	775..795	CDD:275368	7/21 (33%)
		C2H2 Zn finger	803..818	CDD:275368	4/14 (29%)
		C2H2 Zn finger	831..851	CDD:275368	9/21 (43%)
		C2H2 Zn finger	859..877	CDD:275368	7/19 (37%)
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	49/168 (29%)
		C2H2 Zn finger	331..353	CDD:275368	5/47 (11%)
		zf-H2C2_2	345..372	CDD:290200	9/26 (35%)
		C2H2 Zn finger	361..383	CDD:275368	9/21 (43%)
		zf-H2C2_2	375..402	CDD:290200	11/26 (42%)
		C2H2 Zn finger	391..413	CDD:275368	7/21 (33%)
		zf-C2H2	418..440	CDD:278523	7/21 (33%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..458	CDD:290200	8/25 (32%)
		COG5048	442..>519	CDD:227381	24/69 (35%)
		C2H2 Zn finger	448..470	CDD:275368	9/21 (43%)
		zf-H2C2_2	462..489	CDD:290200	10/26 (38%)
		C2H2 Zn finger	478..500	CDD:275368	9/21 (43%)
		DUF3682	862..>931	CDD:289231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457151
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930