DRSC/TRiP Functional Genomics Resources

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Protein Alignment rgr and ZNF888

DIOPT Version :10

Sequence 1:NP_001163089.2 Gene:rgr / 35843 FlyBaseID:FBgn0267792 Length:889 Species:Drosophila melanogaster
Sequence 2:XP_054176943.1 Gene:ZNF888 / 388559 HGNCID:38695 Length:830 Species:Homo sapiens


Alignment Length:893 Identity:185/893 - (20%)
Similarity:301/893 - (33%) Gaps:238/893 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 PPPKTTETPEIDLVY----VVENPLPPSPPPSADISVDELPGSSPQSFDLDPFAVLHEVVTMTPP 185
            |||     |.:...|    ....|.|.||.|                         |..:...||
Human    26 PPP-----PRVCRFYRAGLSAWRPAPTSPRP-------------------------HPYLAQAPP 60

  Fly   186 TPIAPPPGPPTPNPTPTATPAPLPRYETRRVR---QRLCTISSTTINPGQDRLAGQRLSRREPNT 247
            |.:|    |..|...|....:|.|...:|.:.   :||......|          |:..|:...:
Human    61 TSLA----PRRPGFCPVLVDSPGPGSGSRGLEVTLRRLWVCEEET----------QKRKRKAKES 111

  Fly   248 GNAMQRKLRQSQNEQPKDGAVDEVAVEEHKGTEPTGQ-------------------PEKSAMELT 293
            |.|:.:.|...     :|.|: |.:.||.|..:|..:                   ..|..||.:
Human   112 GMALPQGLLTF-----RDVAI-EFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMEFS 170

  Fly   294 PPATPPTPLPPTSPTSSTAS-----CA---------DFQSKSRRELERNHEFVGCLLREYERTEK 344
            ......|.:..|......||     |.         ||..:.:.:....||.....::|...:..
Human   171 SIGKGNTEVIHTGTLQRLASHHIGECCFQEIEKDIHDFVFQWQEDETNGHEAPMTEIKELTGSTD 235

  Fly   345 LWNPRH---PDYKYNAKRSAYGDL--------AGPLESICHRQLSGAEIFAVLKELRCRYRRELK 398
            .::.||   ...||....|.:..|        .|.:.:...:.::.|...:..:.:.||.:..:.
Human   236 QYDQRHAGNKPIKYQLGSSFHSHLPELHIFQPEGKIGNQLEKSINNASSVSTSQRISCRPKTHIS 300

  Fly   399 KVNALGGKYKSRLWYFERMDFLRCVIENRRAEREAKISNESTES----------------EKSCE 447
              |..|..:.......::.|.       .|.|:..:. |||.:|                ||..:
Human   301 --NNYGNNFFHSSLLTQKQDV-------HRKEKSFQF-NESGKSFNCSSLFKKHQIIHLGEKQYK 355

  Fly   448 TDADSCGKSSLYHEVL-------------------------SFILDAFKRQECLWNPQHYDYTTC 487
            .|.  |||.......|                         :::...::|..   ..:.|....|
Human   356 CDV--CGKDFNQKRYLAHHRRCHTGEKPYMCNKCGKVFNKKAYLARHYRRHT---GEKPYKCNEC 415

  Fly   488 CKTELFRDISVQLQEELNYELSGEE--CCNEIQKLRTRYRKELRMVIKHKGLYLPKLWCYDEMEF 550
            .||  |.|.|..|..:..:  :||:  .|||..|:   :.::..:...|:.....|.:...|.  
Human   416 GKT--FSDKSALLVHKTIH--TGEKPYKCNECGKV---FNQQSNLARHHRVHTGEKPYQCKEC-- 471

  Fly   551 LQPILQEQIFNKIS-----KKIGVVGSNQKTKFIDASSIRFDNTEKQLQFVEIYHNYSALWDVDH 610
                  :::|::.|     ::|.......|.|..|.:   |.:.....|.:.|:           
Human   472 ------DKVFSRKSYLERHRRIHTGEKPYKCKVCDKA---FRHDSHLAQHIVIH----------- 516

  Fly   611 PDFRSNTYRSQALGQMLDE-----INTTFHTS---YTAEQLEKTLFNLRKEFSAQKR-------- 659
              .|...|:....|:...|     ::.|.||.   |...:..| :||.:...:...|        
Human   517 --TREKPYKCNECGKTFGENSALLVHKTIHTGEKPYKCNECGK-VFNQQSNLARHHRLHTGEKPY 578

  Fly   660 ------KILTESEDSSSIPLLH------------------AKLAEFLDQNLG--PFRCDICSDLV 698
                  |:.:..........:|                  :.||:....:.|  |::|:.|....
Human   579 KCKECDKVFSRKSHLERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHTVIHTGEKPYKCNECGKTF 643

  Fly   699 KTCDQYKVHRSAHDGTQPFICTLCGKGFQMPCNLTVHIRRHRRDFPYSCEQCDKRFATSTEVAIH 763
            .......:|:..|.|.:.:.|..|||.|....:|..|.|.|..:.||.|.:|.|.|.|.:::|.|
Human   644 VQNSSLVMHKVIHTGEKRYKCNECGKSFNHKSSLAYHHRLHTGEKPYKCNECGKVFRTQSQLACH 708

  Fly   764 LRTHTGERPYICDLCGKSFKTWSFFDIHRRRHLNQSTFHCPICAKGFYEKNRFTDHMNSHWAIRK 828
            .|.||||:||.|:.|.|.|...|..:||||.|..:..:.|.:|.|.|...:....|...|...:.
Human   709 HRLHTGEKPYKCEECDKVFNIKSHLEIHRRVHTGEKPYKCRVCDKAFGRDSYLAQHQRVHTGEKP 773

  Fly   829 HLCTVCGKTFTTYGNLKKHTELHLAVKKYKCGTCGKRFAQFASLRWHK 876
            :.|.||.|.|..|.:|.:||.:|...|.:||..|||.|...::|..|:
Human   774 YKCKVCDKAFKCYSHLAQHTRIHTGEKPFKCSECGKAFRAQSTLIHHQ 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rgrNP_001163089.2 MADF 334..425 CDD:214738 14/101 (14%)
MADF 466..556 CDD:214738 18/91 (20%)
MADF_DNA_bdg 595..682 CDD:463144 17/126 (13%)
C2H2 Zn finger 691..711 CDD:275368 3/19 (16%)
C2H2 Zn finger 719..739 CDD:275368 8/19 (42%)
COG5048 742..>824 CDD:227381 31/81 (38%)
C2H2 Zn finger 747..767 CDD:275368 8/19 (42%)
C2H2 Zn finger 775..795 CDD:275368 9/19 (47%)
C2H2 Zn finger 803..818 CDD:275368 4/14 (29%)
C2H2 Zn finger 831..851 CDD:275368 9/19 (47%)
C2H2 Zn finger 859..877 CDD:275368 7/18 (39%)
ZNF888XP_054176943.1 KRAB 119..160 CDD:460171 8/46 (17%)
C2H2 Zn finger 329..348 CDD:275368 4/18 (22%)
C2H2 Zn finger 356..376 CDD:275368 5/21 (24%)
C2H2 Zn finger 384..404 CDD:275368 0/19 (0%)
zf-H2C2_2 396..420 CDD:463886 5/28 (18%)
C2H2 Zn finger 412..432 CDD:275368 7/21 (33%)
COG5048 436..820 CDD:227381 98/411 (24%)
C2H2 Zn finger 440..460 CDD:275368 5/22 (23%)
C2H2 Zn finger 468..488 CDD:275368 3/27 (11%)
C2H2 Zn finger 496..516 CDD:275368 4/22 (18%)
C2H2 Zn finger 524..544 CDD:275368 3/19 (16%)
C2H2 Zn finger 552..572 CDD:275368 4/20 (20%)
C2H2 Zn finger 580..600 CDD:275368 1/19 (5%)
C2H2 Zn finger 608..628 CDD:275368 2/19 (11%)
C2H2 Zn finger 636..656 CDD:275368 3/19 (16%)
C2H2 Zn finger 664..684 CDD:275368 8/19 (42%)
C2H2 Zn finger 692..712 CDD:275368 8/19 (42%)
C2H2 Zn finger 720..740 CDD:275368 9/19 (47%)
C2H2 Zn finger 748..768 CDD:275368 5/19 (26%)
C2H2 Zn finger 776..796 CDD:275368 9/19 (47%)
C2H2 Zn finger 804..824 CDD:275368 7/18 (39%)

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