DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rgr and Blimp-1

DIOPT Version :9

Sequence 1:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster

Alignment Length:	944	Identity:	188/944 - (19%)
Similarity:	316/944 - (33%)	Gaps:	265/944 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 MDHIRVQHTQDVSRRYETEEERCPQTDLVIMELDCPEIYPPEAPRKCSWEADMDIQLMSLVPSPP 117
            |:.:..||.:::  .:.|..:..|..:|::.       |..:...:..::.|.:..:......
  Fly   225 MNLVACQHQENI--YFYTTRDILPNEELMVW-------YCKDFASRLGYDVDPETTIFGACKQ-- 278

  Fly   118 AVHIAPLPPPKTTETPEIDLVYVVENPLPPSPPPSADISVD--------ELP---GSSPQSFDLD 171
            ||........:..|....|.......|.|..||   |::|.        .||   |:.|.:
  Fly   279 AVEAEEEADEEEEEAEGEDGKPRYSMPAPEIPP---DVAVSHITYVMGLHLPVGAGNGPAN---- 336

  Fly   172 PFAVLHEVVTMTPPTPIAPP----PGPPTPNPTPTAT-PAPLPRYETRRVRQRLCTISSTTINPG 231
             .:|...|...|||.|.|.|    ..||....|.|:| .|..|..:..|         ..::..|
  Fly   337 -GSVAGSVSGATPPPPTATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGR---------HASVIIG 391

  Fly   232 QDR---------LAGQRLS----RREPNTGNAMQRKLRQSQ----NE-------QPKDGAVDEVA 272
            |||         .||..||    :..|..|:.  |.:|..:    ||       .|:|.:..|
  Fly   392 QDRSPMASSDKDTAGSPLSGLDHQMTPQDGSV--RSVRSDEGYHSNECHEDGLTPPEDSSDSE-- 452

  Fly   273 VEEH--------KGTEP----TGQPEKSAMELTPPA------TPPTPLPPTSPTSSTASCADFQS 319
             .||        |...|    ..|.:|.:.  :|||      |..:.:..:||| :|..|...::
  Fly   453 -SEHNYVLDCSKKAIAPKETVIAQAQKPSS--SPPAVVMANTTTNSMISHSSPT-ATPICETDKN 513

  Fly   320 KSRR---ELERNHEFVG--CL-----LREYERTEKLWNPR--------HPDYKYNAKRSAYGDLA 366
            :.|:   ::...:||..  |:     |:|.::...|  |:        ||:
  Fly   514 EYRKFKVKMPLKYEFKNKTCVKQEPSLKEVDQEMSL--PQEEEEDQVMHPE-------------- 562

  Fly   367 GPLESICHRQLS--GAEIFAVLKELRCRYRRELKKVNALGGKYKSRLWYFERMDFLRCVIENRRA 429
             | :|||....:  |.|...:::..|.|.|..::
  Fly   563 -P-DSICPSTTTHLGDEHMLMMERERERERERIQ------------------------------- 594

  Fly   430 EREAKISNESTESEKSCETDADSCGK-------SSLYHE-------VLSFILDAFKRQECLWNPQ 480
            |||.  ||:...|......:.:|.|:       |..|:|       .:.|...:....|.:...|
  Fly   595 EREP--SNQQPASSTVIVLEHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQPSSSILETILTSQ 657

  Fly   481 HYDYTTCCKTELFRDISVQLQEELNYELSGEECCNEIQKLRTRYRKELRMVIKHKGLYLPKLWCY 545
            |                     .|....:....|.:.............|...:|
  Fly   658 H---------------------RLEAAAAAANACRQANAATPPPTSPTEMAYSYK---------- 691

  Fly   546 DEMEFLQPILQEQIFN------KISKKIGVVGSNQKTKFIDASSIRFDNTEKQLQFVEIYHNYSA 604
            ....:...:..:...|      ::|....|||..:.|:   |:.|:.:.:...    ..:|:::.
  Fly   692 KSQRYGNAVSPDSSSNLGQNPEQLSSSAVVVGEQEMTR---ATMIKGECSPPP----PSHHHHNV 749

  Fly   605 LWDVDH----------------PDFRSNTYRSQALGQMLDEINTTFHTSYTAEQLEKTLFNLRKE 653
            ::....                |.:....:...|       ..:|||   :......:.|:.:..
  Fly   750 IFSPSRHAAYLGAGEAGGHSPSPGYPGYPHYGAA-------ATSTFH---SPPHSSHSPFDRQSN 804

  Fly   654 F-----SAQKRKILTESEDSSSIPLLHAKLAEFLDQNLGPFRCDICSDLVKTCDQYKVHRSAHDG 713
            .     ||....:|..|....:.||:. .|...  |.|.|.|....|.|  :.|.....||   |
  Fly   805 ASSGAGSATNLHLLQTSTQMLNHPLMQ-PLTPL--QRLSPLRISPPSSL--SPDGNSCPRS---G 861

  Fly   714 TQPFICTLCGKGFQMPCNLTVHIRRHRRDFPYSCEQCDKRFATSTEVAIHLRTHTGERPYICDLC 778
            :.....:|..:|::   :|...:::......|.|..|.|.|...:.:.:|||||:||||:.|::|
  Fly   862 SPLSPNSLASRGYR---SLPYPLKKKDGKMHYECNVCCKTFGQLSNLKVHLRTHSGERPFKCNVC 923

  Fly   779 GKSFKTWSFFDIHRRRHLNQSTFHCPICAKGFYEKNRFTDHMNSHWAIRKHLCTVCGKTFTTYGN 843
            .|||...:....|...|..:....|.||.|.|...:....|:..|...:.:.|.:|.:.||.:.:
  Fly   924 TKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLHSGQKPYACDLCPQKFTQFVH 988

  Fly   844 LKKHTELHLAVKKYKCGTCGKRFAQFASLRWHKK 877
            ||.|..||...:.|.|..|.|::...:.||.|.|
  Fly   989 LKLHKRLHTNDRPYVCQGCDKKYISASGLRTHWK 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510	15/99 (15%)
		MADF_DNA_bdg	465..551	CDD:287510	8/85 (9%)
		MADF_DNA_bdg	595..682	CDD:287510	14/107 (13%)
		C2H2 Zn finger	691..711	CDD:275368	5/19 (26%)
		C2H2 Zn finger	719..739	CDD:275368	3/19 (16%)
		zf-H2C2_2	731..756	CDD:290200	6/24 (25%)
		COG5048	742..>824	CDD:227381	27/81 (33%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		zf-H2C2_2	763..784	CDD:290200	14/20 (70%)
		C2H2 Zn finger	775..795	CDD:275368	6/19 (32%)
		C2H2 Zn finger	803..818	CDD:275368	5/14 (36%)
		C2H2 Zn finger	831..851	CDD:275368	7/19 (37%)
		C2H2 Zn finger	859..877	CDD:275368	6/17 (35%)
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	7/43 (16%)
		C2H2 Zn finger	892..912	CDD:275368	7/19 (37%)
		zf-H2C2_2	904..929	CDD:290200	14/24 (58%)
		C2H2 Zn finger	920..940	CDD:275368	6/19 (32%)
		zf-H2C2_2	932..957	CDD:290200	7/24 (29%)
		C2H2 Zn finger	948..968	CDD:275368	6/19 (32%)
		zf-H2C2_2	960..985	CDD:290200	5/24 (21%)
		C2H2 Zn finger	976..996	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1004..1023	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840