DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rgr and CG12605

DIOPT Version :9

Sequence 1:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	320	Identity:	83/320 - (25%)
Similarity:	122/320 - (38%)	Gaps:	62/320 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   546 DEMEFLQPILQEQIFNKISKKIGVVGSNQKT-KFIDASSIRFDNTEKQLQFVEIYHNYSALW--- 606
            ::.:...|.:|| |.|..|.:     |.|.| :||.:||........     |..:|.|.|.
  Fly   273 EQEQLRSPEIQE-ISNSASSR-----SPQSTIRFIGSSSYDLMGGSS-----EGANNCSPLTPPN 326

  Fly   607 -----DVD---------------HPDFRSNTYRSQALGQMLDEINTTFHTSYTAEQLEKTLFNLR 651
                 |||               .|:.:.|..|:.||...|:.::.....|..|...::.    |
  Fly   327 SDHSSDVDIDMSSSSESGLQQWGKPNPQQNQQRASALKMCLNMLDGRTKASKAAAVTKQD----R 387

  Fly   652 KEFSAQKRKILTESEDSS------------SIPLLHAKLA---EFLDQNLGPFRCDICSDLVKTC 701
            :| ..|.|....:|..||            :..|.|:...   .:..:..|.::|..|.....|.
  Fly   388 QE-PMQPRPKSAQSNASSGGGPPSEPPENPAASLGHSSSGNGENYAKRKRGCYKCCECGKQYATS 451

  Fly   702 DQYKVHRSAH---DGTQPFICTLCGKGF-QMPCNLTVHIRRHRRDFPYSCEQCDKRFATSTEVAI 762
            .....|:..|   |......|..|||.: .||. |.:|:..|:  ..:||:.|.|.|:....:..
  Fly   452 SNLSRHKQTHRSLDSQSAKKCNTCGKAYVSMPA-LAMHLLTHK--LSHSCDICGKLFSRPWLLQG 513

  Fly   763 HLRTHTGERPYICDLCGKSFKTWSFFDIHRRRHLNQSTFHCPICAKGFYEKNRFTDHMNS 822
            |||:||||:||.|..|||:|...|....|.:.|.....|.|..|.|.|..|:....|:.|
  Fly   514 HLRSHTGEKPYACVHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKHLES 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510
		MADF_DNA_bdg	465..551	CDD:287510	0/4 (0%)
		MADF_DNA_bdg	595..682	CDD:287510	24/124 (19%)
		C2H2 Zn finger	691..711	CDD:275368	4/19 (21%)
		C2H2 Zn finger	719..739	CDD:275368	8/20 (40%)
		zf-H2C2_2	731..756	CDD:290200	8/24 (33%)
		COG5048	742..>824	CDD:227381	30/81 (37%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		zf-H2C2_2	763..784	CDD:290200	14/20 (70%)
		C2H2 Zn finger	775..795	CDD:275368	7/19 (37%)
		C2H2 Zn finger	803..818	CDD:275368	5/14 (36%)
		C2H2 Zn finger	831..851	CDD:275368
		C2H2 Zn finger	859..877	CDD:275368
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	4/21 (19%)
		C2H2 Zn finger	441..461	CDD:275370	4/19 (21%)
		C2H2 Zn finger	472..492	CDD:275368	8/20 (40%)
		COG5048	492..>570	CDD:227381	29/79 (37%)
		zf-C2H2	496..518	CDD:278523	8/21 (38%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	511..534	CDD:290200	13/22 (59%)
		zf-C2H2	524..546	CDD:278523	8/21 (38%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	538..562	CDD:290200	6/23 (26%)
		C2H2 Zn finger	554..571	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457109
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930