DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rgr and CG11906

DIOPT Version :9

Sequence 1:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_611402.2	Gene:	CG11906 / 37209	FlyBaseID:	FBgn0034425	Length:	634	Species:	Drosophila melanogaster

Alignment Length:	664	Identity:	122/664 - (18%)
Similarity:	216/664 - (32%)	Gaps:	217/664 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 ATPPTPLPPTSPTSSTASCADFQSKSRRELERNHEFVGCLLREYERTEKLWNPRHPDYKYNAKRS 360
            ||.|.|    .|:|:..:|: .:..:|::.:.||  ||. .||.|.     |..:......||.|
  Fly     4 ATAPDP----EPSSTNGNCS-VEHDNRQDQDENH--VGA-EREAEA-----NDANCTVCGAAKAS 55

  Fly   361 AYGDL---------------------AGPLESIC---------HRQ------------------- 376
            |..||                     ...|::||         |.:
  Fly    56 ALLDLRSNHVMQRRLSRDWKIHADVIRSTLKAICVECVCKLNMHSEVTRSLMQRMQRLQRSGGET 120

  Fly   377 ----------------LSGAEIFAVLKE-----------LRCR-----------------YRREL 397
                            ::.||:...|.|           :|.|                 ..:|.
  Fly   121 TKVTTTTTSPSQHSPPIADAEVSTTLIESQEEVAHSGQSVRSRSSCSVLEVYLAQQPYSPSAKET 185

  Fly   398 KKVNALGGKYKSRL-------WYFERMDFL-----RCVIENRRAEREAKIS----NESTESEKSC 446
            ::.:|.|.|:::||       .||.| |:.     ||....|:..|.:::.    ||::..|
  Fly   186 EEKHAEGWKWRTRLECHECGRAYFRR-DYYAQHLRRCSKTRRKQPRPSRVKCRVLNEASYDE--- 246

  Fly   447 ETDADSCGKSSLYHEVLSFILDAFKRQECLWNPQHYDYTTCCKTELFRDISVQLQEELNYELSGE 511
            |..:.:...|.:|                        |...|..|....||.:..|.:.::....
  Fly   247 EAPSRAIRSSRIY------------------------YCRHCDAEFETLISKRQHERMKHQQRYP 287

  Fly   512 -ECCNEIQKLRTRYRKELRMVI---KHKGLYLPKLWCYDEMEFLQPILQEQIFNKISKK------ 566
             :.|.  .:|.|:|..|:...|   |.:.|.:     .::.|..|.::..::....|.:
  Fly   288 CDLCE--AQLDTKYEWEMHHTICQAKQEALAI-----VEQQEAGQTVMTSRVPRACSMRSRSRAC 345

  Fly   567 --------IGVVGSNQKTKFIDASSIRFDNTEKQLQFVEIYHNYSALWDVDHPDFRSNTYRSQAL 623
                    :.....:::.:.|::.....:..|:...:.. ..|::..|.|:|....||:..:.:|
  Fly   346 SEAWDRYDMDEEEEDEEDEEIESGGEELEEGEEDAMYAR-RMNFTGDWIVNHSRSNSNSAGNLSL 409

  Fly   624 -----GQMLDEINTTFHTSYTAEQLE--KTLFNLRKEFSAQKRKILTESEDSSSIPLLHAKLAEF 681
                 |.:  |.:.|....|....|:  ||...| |.|:.     .|......:..|:.....::
  Fly   410 LYGDYGMV--ETHMTTDKEYDLYLLDLLKTQVRL-KSFTC-----FTPDCGYQTDTLVALMKHDY 466

  Fly   682 LDQ-NLGPFRCDICSDLVKTCDQYKVHRSAHDGTQP---FICTLCGKGFQMPCNLTVHIRRHRRD 742
            ::. .:..|.|..|.|:..:    ||....|...|.   :||..|.:.|::...|..|.:.||:.
  Fly   467 MEHWKMSWFYCHKCGDVFTS----KVFLDYHMHLQNRGLYICHKCREEFELQHQLDRHFQLHRKG 527

  Fly   743 FPYSCEQCDKRFATSTEVAIHLRTHTGERPYICDLCGKSFKTWSFFDIHR-----RRHLNQSTFH 802
            ..|.|..|...|.:..::..|           |...|.|........|.|     ..|:.:|:.:
  Fly   528 INYHCNFCRLEFLSEAKLLAH-----------CKKLGHSPNDEPLISIDRSLSIVNCHVPRSSDY 581

  Fly   803 CPICAKGFYEKNRF 816
            ..|...  ||:..|
  Fly   582 SRIVKS--YEEREF 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510	30/184 (16%)
		MADF_DNA_bdg	465..551	CDD:287510	15/89 (17%)
		MADF_DNA_bdg	595..682	CDD:287510	19/93 (20%)
		C2H2 Zn finger	691..711	CDD:275368	5/19 (26%)
		C2H2 Zn finger	719..739	CDD:275368	5/19 (26%)
		zf-H2C2_2	731..756	CDD:290200	8/24 (33%)
		COG5048	742..>824	CDD:227381	16/80 (20%)
		C2H2 Zn finger	747..767	CDD:275368	4/19 (21%)
		zf-H2C2_2	763..784	CDD:290200	4/20 (20%)
		C2H2 Zn finger	775..795	CDD:275368	5/24 (21%)
		C2H2 Zn finger	803..818	CDD:275368	4/14 (29%)
		C2H2 Zn finger	831..851	CDD:275368
		C2H2 Zn finger	859..877	CDD:275368
CG11906	NP_611402.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930