DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rgr and Zfp52

DIOPT Version :9

Sequence 1:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001014180.1	Gene:	Zfp52 / 361487	RGDID:	1359149	Length:	755	Species:	Rattus norvegicus

Alignment Length:	718	Identity:	149/718 - (20%)
Similarity:	259/718 - (36%)	Gaps:	180/718 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 MQRKLRQSQNEQPKDG--AVDEVAVEEHKGTEPTGQPEKSAMELTPPATPPTPLPPTSPTSSTAS 313
            |:||...:::.:|:.|  .:.:..::|.|..|..                      .||.:.:.|
  Rat     1 MERKETVAKDPEPQSGHSLLFKEKIKEEKQEEMA----------------------DSPVNMSQS 43

  Fly   314 CADFQSK----SRRELERNHEFVGCLLREYERTEKLWNPRHPDYKYNAKRSAYGDLAGPLESICH 374
            ...|:..    |:.|.|       ||                   .:::|:.|.|:.  ||:  :
  Rat    44 LLTFRDVAVHFSQEEWE-------CL-------------------DSSQRALYIDVM--LEN--Y 78

  Fly   375 RQLSGAEIFAVLKEL--RCRYRRELKKVNALGGKYK--SRLWYFERMDFL------RCVIENRRA 429
            ..|...|.:.:.:.:  ..:..:|..:.|.||...:  |....::|.|.:      || .::|.|
  Rat    79 SNLVSVENYCICETVHQHVKTEKESCQCNELGEMLRGPSNCALYKRSDTIETSNNCRC-CKDRGA 142

  Fly   430 EREAKISNESTE--------SEKSCETDADSCG---------------KSSLYHEVLSFILDAFK 471
            ..::...::.|.        :.|:||.....|.               |...|.:..|......:
  Rat   143 SVDSSNPDQHTSTHTGEEPCTSKNCEKSFSLCSNIREDQRLYTAKKEHKQDEYDDRFSSTYSLMQ 207

  Fly   472 RQECLWNPQHYDYTTC--CKTELFRDISVQLQEELNYELSGEE--CCNEIQKLRTRYRKELRMVI 532
            :...:....|    .|  |:..:....|:.|.:.::   :||:  .||..:|...::.:    :.
  Rat   208 QTVDMGEKPH----QCGPCRKYINTTSSLSLHQRIH---TGEKPYKCNICEKSFNQWSR----LK 261

  Fly   533 KHKGLYL--PKLWCYD-EMEFLQPILQEQIFNKISKKIGVVGSN-QKTKFIDASSIRFDNTEKQL 593
            .|:.|::  .:..|.: .|.|:      |:|...|.:....|.. .|.|..|.|
  Rat   262 THQILHISEKQYKCKEGRMSFV------QVFAHKSHQRRHTGEKPYKCKECDRS----------- 309

  Fly   594 QFVEIYHNYSALW--DVDHPDFRSNTYRSQALGQMLDEIN--------TTFHTSY------TAEQ 642
                ..|..|..|  .:..|:..   |..:..|:...|::        .|....|      |:..
  Rat   310 ----FAHCASLRWHQKIHSPEVH---YECKECGKAFSELSHLKMHYRIHTVEKPYRYEECDTSST 367

  Fly   643 LEKTLFNLRKEFSAQKRKILTESEDSSSIPLLHAKLAEFLDQNLGPFRCDICSDLVKTCDQYKVH 707
            :..||.|.:|..:.:|.....|. |.|.....:.:..:.:...:.|:||..|.....|....:.|
  Rat   368 VNSTLKNHQKIHTREKPYRYREC-DKSITKCSYLRTYQRVHTGMRPYRCTECDKSFTTYSNLRQH 431

  Fly   708 RSAHDGTQP----------------------------FICTLCGKGFQMPCNLTVHIRRHRRDFP 744
            :..|.|.:|                            :.|..|.:.|....||.||.|.|..:.|
  Rat   432 QKIHTGEKPPNCKGSDKSFLRISSVRKHQKIHAGERRYGCKECSRSFTWFSNLRVHQRVHTGERP 496

  Fly   745 YSCEQCDKRFATSTEVAIHLRTHTGERPYICDLCGKSFKTWSFFDIHRRRHLNQSTFHCPICAKG 809
            |.|:.|||.|.|.:.:.:|.:.||||:||.|..|..||...|....|::.|..:..:.|..|.|.
  Rat   497 YRCKDCDKSFTTGSNLRVHQKIHTGEKPYKCKDCDISFLWISNLRTHQKIHTGEKPYKCQECKKS 561

  Fly   810 FYEKNRFTDHMNSHWAIRKHLCTVCGKTFTTYGNLKKHTELHLAVKKYKCGTCGKRFAQFASLRW 874
            |...:...||...|...:.:.|..|..:|....:|::|.::|...|.|||..|.|.|.|.::||.
  Rat   562 FTRCSYLRDHQKIHTGEKLYKCKDCNVSFMWISSLRRHQKIHTGEKPYKCRECEKSFTQCSTLRD 626

  Fly   875 HKK 877
            |:|
  Rat   627 HQK 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510	15/88 (17%)
		MADF_DNA_bdg	465..551	CDD:287510	14/92 (15%)
		MADF_DNA_bdg	595..682	CDD:287510	18/102 (18%)
		C2H2 Zn finger	691..711	CDD:275368	4/19 (21%)
		C2H2 Zn finger	719..739	CDD:275368	8/19 (42%)
		zf-H2C2_2	731..756	CDD:290200	13/24 (54%)
		COG5048	742..>824	CDD:227381	28/81 (35%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		zf-H2C2_2	763..784	CDD:290200	11/20 (55%)
		C2H2 Zn finger	775..795	CDD:275368	6/19 (32%)
		C2H2 Zn finger	803..818	CDD:275368	4/14 (29%)
		C2H2 Zn finger	831..851	CDD:275368	5/19 (26%)
		C2H2 Zn finger	859..877	CDD:275368	8/17 (47%)
Zfp52	NP_001014180.1	KRAB	44..84	CDD:396083	12/69 (17%)
		C2H2 Zn finger	219..239	CDD:275368	4/19 (21%)
		SFP1	<241..324	CDD:227516	21/107 (20%)
		C2H2 Zn finger	247..295	CDD:275368	11/57 (19%)
		C2H2 Zn finger	303..323	CDD:275368	6/34 (18%)
		COG5048	329..702	CDD:227381	79/302 (26%)
		C2H2 Zn finger	331..351	CDD:275368	2/19 (11%)
		C2H2 Zn finger	359..379	CDD:275368	5/19 (26%)
		C2H2 Zn finger	388..407	CDD:275368	3/19 (16%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		C2H2 Zn finger	443..463	CDD:275370	0/19 (0%)
		C2H2 Zn finger	471..491	CDD:275368	8/19 (42%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		C2H2 Zn finger	639..659	CDD:275368
		C2H2 Zn finger	667..687	CDD:275368
		C2H2 Zn finger	695..715	CDD:275368
		zf-H2C2_2	707..730	CDD:404364
		C2H2 Zn finger	723..743	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000