DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rgr and ZSCAN29

DIOPT Version :9

Sequence 1:	NP_001163089.2	Gene:	rgr / 35843	FlyBaseID:	FBgn0267792	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001359009.1	Gene:	ZSCAN29 / 146050	HGNCID:	26673	Length:	852	Species:	Homo sapiens

Alignment Length:	958	Identity:	207/958 - (21%)
Similarity:	322/958 - (33%)	Gaps:	272/958 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 FMDHIRVQHTQDVSRRYETEEERCPQTDLVIMELDCPEIYPPEAPRKCSWEADMDIQLMSLVPSP 116
            |....|..|.|:|:...|...:        :.||.|..:.|....::...|..:..|.::::|..
Human    17 FRQRFRRFHYQEVAGPREAFSQ--------LWELCCRWLRPEVRTKEQIVELLVLEQFLTVLPGE 73

  Fly   117 PAVHIAPLPPPKTTETPEIDLVYVVENPLPPSPPPSADISVDELPGSSPQSFDLDPFAVLHEVVT 181
            ....:....|....|.  :.||..:|.. |..|..|..:||      ..|...|:         .
Human    74 IQNWVQEQCPENGEEA--VTLVEDLERE-PGRPRSSVTVSV------KGQEVRLE---------K 120

  Fly   182 MTPPTPIAPPPGPPTPNPTPTATPAPLPRYETRRVRQRLCTISSTTINPGQDRLAGQRLSRREPN 246
            ||||                             :..|.|.::...::.| |.|...::...|.|:
Human   121 MTPP-----------------------------KSSQELLSVRQESVEP-QPRGVPKKERARSPD 155

  Fly   247 TGNAMQ----RKLRQSQNEQ---PKDGAVDEVAVEEHKGTEPTGQPEKSAMELTPPATPPTPLPP 304
            .|...|    .||:..|...   ||.|.|..:...|....:..|..||.             ||.
Human   156 LGPQEQMNPKEKLKPFQRSGLPFPKSGVVSRLEQGEPWIPDLLGSKEKE-------------LPS 207

  Fly   305 TSPTSSTASCADF--QSKSRRE-LERNH-----EFVGCLLREYERTEKLWNPRHPDYKYNAKRSA 361
            .|........||.  ..|.||. :|::|     |.|..:...||.|..|.........|.|.|:
Human   208 GSHIGDRRVHADLLPSKKDRRSWVEQDHWSFEDEKVAGVHWGYEETRTLLAILSQTEFYEALRN- 271

  Fly   362 YGDLAGPLESICHR--QLSGA--------EIFAVLKELRCRYR---RELKKVNALGGKYKSRLWY 413
                       |||  |:.||        .....|::.|.:::   :..:||.:  |.......:
Human   272 -----------CHRNSQVYGAVAERLREYGFLRTLEQCRTKFKGLQKSYRKVKS--GHPPETCPF 323

  Fly   414 FERMDFLR----CVIENRRAEREAKIS-------------------NESTESEKSCETDADSCGK 455
            ||.|:.|.    ..:.:...|..|..|                   .|..|...:.|:|:|....
Human   324 FEEMEALMSAQVIALPSNGLEAAASHSGLVGSDAETEEPGQRGWQHEEGAEEAVAQESDSDDMDL 388

  Fly   456 SSL---------------------YHEVLSFILDAFKRQECLWNPQHYDYTTCC--KTELFRDIS 497
            .:.                     |.|..:::       ..|...|.|:....|  .::|:..::
Human   389 EATPQDPNSAAPVVFRSPGGVHWGYEETKTYL-------AILSETQFYEALRNCHRNSQLYGAVA 446

  Fly   498 VQLQEELNYELSGEECCNEIQKLRTRYRKELRMVIKHKGLYLPKLWC--YDEMEFLQPIL----- 555
            .:|. |..:..:.|:|..:.:.|:|.|||.       |....|:. |  ::||:.|..:.
Human   447 ERLW-EYGFLRTPEQCRTKFKSLQTSYRKV-------KNGQAPET-CPFFEEMDALVSVRVAAPP 502

  Fly   556 ---QEQIFNKISKKIGVVGSN-----------------------------------------QKT 576
               ||:     :....|.|::                                         |..
Human   503 NDGQEE-----TASCPVQGTSEAEAQKQAEEADEATEEDSDDDEEDTEIPPGAVITRAPVLFQSP 562

  Fly   577 KFIDASSIRFDNTEKQL-QFVEIYHNYSALWDVDHPDFRSNTYRSQALGQMLDEINTTFHTSYTA 640
            :..:|.....||:::.: :.|:::....|..:...|     .|..|..|...|        ..:.
Human   563 RGFEAGFENEDNSKRDISEEVQLHRTLLARSERKIP-----RYLHQGKGNESD--------CRSG 614

  Fly   641 EQLEKTLFNLRKEFSAQKRKILTESEDSSS------IPLLHAKLAEFL--DQNLGPFRCDICSDL 697
            .|..||        |.:||..||..|.|.|      .|.|..:..::|  .::.||
Human   615 RQWAKT--------SGEKRGKLTLPEKSLSEVLSQQRPCLGERPYKYLKYSKSFGP--------- 662

  Fly   698 VKTCDQYKVHRSAHDGTQPFICTLCGKGFQMPCNLTVHIRRHRRDFPYSCEQCDKRFATSTEVAI 762
                :...:|:.:|....|:.|..|||.|.....|..|.|.|..:.||.|..|.|.|..|:....
Human   663 ----NSLLMHQVSHQVENPYKCADCGKSFSRSARLIRHRRIHTGEKPYKCLDCGKSFRDSSNFIT 723

  Fly   763 HLRTHTGERPYICDLCGKSFKTWSFFDIHRRRHLNQSTFHCPICAKGFYEKNRFTDHMNSHWAIR 827
            |.|.||||:||.|..|||.|...|...||:|.|..:..:.|..|.|.|...:.|:.|...|...|
Human   724 HRRIHTGEKPYQCGECGKCFNQSSSLIIHQRTHTGEKPYQCEECGKSFNNSSHFSAHRRIHTGER 788

  Fly   828 KHLCTVCGKTFTTYGNLKKHTELHLAVKKYKCGTCGKRFAQFASLRWH 875
            .|:|..|||:|:...:|:.|...|...|.|.|..|||.|::.::|..|
Human   789 PHVCPDCGKSFSKSSDLRAHHRTHTGEKPYGCHDCGKCFSKSSALNKH 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgr	NP_001163089.2	MADF_DNA_bdg	335..420	CDD:287510	21/97 (22%)
		MADF_DNA_bdg	465..551	CDD:287510	19/89 (21%)
		MADF_DNA_bdg	595..682	CDD:287510	20/92 (22%)
		C2H2 Zn finger	691..711	CDD:275368	1/19 (5%)
		C2H2 Zn finger	719..739	CDD:275368	8/19 (42%)
		zf-H2C2_2	731..756	CDD:290200	10/24 (42%)
		COG5048	742..>824	CDD:227381	31/81 (38%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		zf-H2C2_2	763..784	CDD:290200	13/20 (65%)
		C2H2 Zn finger	775..795	CDD:275368	9/19 (47%)
		C2H2 Zn finger	803..818	CDD:275368	5/14 (36%)
		C2H2 Zn finger	831..851	CDD:275368	7/19 (37%)
		C2H2 Zn finger	859..877	CDD:275368	7/17 (41%)
ZSCAN29	NP_001359009.1	SCAN	14..124	CDD:128708	27/132 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..182		26/131 (20%)
		Myb_DNA-bind_4	245..330	CDD:372747	21/98 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..400		7/52 (13%)
		Myb_DNA-bind_4	408..493	CDD:372747	21/100 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..557		4/59 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..625		7/37 (19%)
		COG5048	<630..838	CDD:227381	71/220 (32%)
		C2H2 Zn finger	680..700	CDD:275368	8/19 (42%)
		C2H2 Zn finger	708..728	CDD:275368	7/19 (37%)
		C2H2 Zn finger	736..756	CDD:275368	9/19 (47%)
		C2H2 Zn finger	764..784	CDD:275368	6/19 (32%)
		C2H2 Zn finger	792..812	CDD:275368	7/19 (37%)
		C2H2 Zn finger	820..840	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910