DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rgr and si:dkey-34m19.3

DIOPT Version :9

Sequence 1:NP_001163089.2 Gene:rgr / 35843 FlyBaseID:FBgn0267792 Length:889 Species:Drosophila melanogaster
Sequence 2:XP_002662346.1 Gene:si:dkey-34m19.3 / 100005466 ZFINID:ZDB-GENE-030131-2206 Length:619 Species:Danio rerio


Alignment Length:887 Identity:183/887 - (20%)
Similarity:268/887 - (30%) Gaps:368/887 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 PDVQSFGFNCAFCPAICLQFSVFMDHIRVQHTQDVSRRYETEEERCPQTDLVIMELDCPEIYPPE 94
            |..:|...:|.|.|                  :|..|..:|...|    |.||     |.|:...
Zfish    60 PKPRSLLCSCHFRP------------------EDFDRTGQTVRLR----DGVI-----PSIFNFS 97

  Fly    95 AP-RKCSWEADMDIQLMSLVPSPPAVHIAPLPPPKTTETPEIDLVYVVENPLPPS---------- 148
            .| .|.|..:.......:...|||     |.||.:.||...::    ..:.||.|          
Zfish    98 NPLSKLSISSSSKTSKKAAEQSPP-----PKPPTQATEPDPLE----SSDSLPKSSSRRSSKKAV 153

  Fly   149 ---PPPSADISVDELPGSSP---QSFDLDPFAVLHEVVTMTPPTPIAPPPGPPTP--NPTPTATP 205
               |||..|     .|.|.|   :|.|..|.:...|  |.......:|||.|.||  .|.|..:.
Zfish   154 KQNPPPKPD-----TPASKPDPLESADSVPSSSSSE--TSKKAAEQSPPPKPHTPASEPDPLESA 211

  Fly   206 APLPRYETRRVRQRLCTISSTTINPGQDRLAGQRLSRREPNTGNAMQRKLRQSQNEQPKDGAV-- 268
            ..||:..:||                                  :.::..:||...:| |..|  
Zfish   212 DSLPKSSSRR----------------------------------SSKKAAKQSPPSKP-DTPVTK 241

  Fly   269 -DEVAVEEHKGTEPTGQPEKSAMELTPPATPPTPLPPTSPTSSTASCADF---QSKSRRELERNH 329
             |.:...:...:..:|:..|.|:|.:||..|.||.....|..|:.|...:   ..|::::|..:.
Zfish   242 PDPLESADPLPSSSSGETSKKAVEQSPPPKPHTPATEPDPLESSDSDHPYALNPVKAKKKLSESQ 306

  Fly   330 EFVGCLLREYERTEKLWNPRHPDYKYNAKRSAYGDLAGPLESICHRQLSGAEIFAVLKELRCRYR 394
            |.|..|.||                                               |:..|.|.|
Zfish   307 EQVDKLRRE-----------------------------------------------LRNARDRER 324

  Fly   395 RELKKVNALGGKYKSRLWYFERMDFLRCVIENRRAEREAKISNESTESEKSCETDADSCGKSSLY 459
            |:.|.:.:|                                                        
Zfish   325 RQKKTMKSL-------------------------------------------------------- 333

  Fly   460 HEVLSFILDAFKRQECLWNPQHYDYTTCCKTELFRDISVQLQEELNY--ELSGEECCNEIQKLRT 522
                   |:..|::..|             ||       :|||:||:  ||.|..          
Zfish   334 -------LEDLKKKNML-------------TE-------ELQEQLNFFSELIGGN---------- 361

  Fly   523 RYRKELRMVIKHKGLYLPKLWCYDEMEFLQPILQEQIFNKISKKIGVVGSNQKTKFIDASSIRFD 587
                                   ||.|      :|:..||..     |.:.:|.:          
Zfish   362 -----------------------DESE------EERAGNKPR-----VRAKKKKR---------- 382

  Fly   588 NTEKQLQFVEIYHNYSALWDVDHPDFRSNTYRSQALGQMLDEINT--TFHTSYTAEQLEKTLFNL 650
                                      ..||:.....|:.|..|:.  |....:|.|:        
Zfish   383 --------------------------NRNTFICTECGKTLASIHNLKTHMMIHTGEK-------- 413

  Fly   651 RKEFSAQKRKILTESEDSSSIPLLHAKLAEFLDQNLGPFRCDICSDLVKTCDQYKVHRSAHDGTQ 715
                                                 ||.||.|....:....:|.|...|.|.:
Zfish   414 -------------------------------------PFPCDQCGKSFRQPSDHKQHMMTHTGEK 441

  Fly   716 PFICTLCGKGFQMPCNLTVHIRRHRRDFPYSCEQCDKRFATSTEVAIHLRTHTGERPYICDLCGK 780
            |:.|.:|.|.|....||.:|:|.|.::.||||..|.|.|:.|:.:..|.:.|||.:.::|..|||
Zfish   442 PYKCNVCDKAFASASNLKLHLRVHTKEKPYSCSVCGKSFSQSSSLKTHQKIHTGVKEHVCLECGK 506

  Fly   781 SFKTWSFFDIHRRRHLNQSTFHCPICAKGFYEKNRFTDHMNSHWAIRKHLCTVCGKTFTTYGNLK 845
            ||.|......|:|.|..:..:.|..|.:||.:.:....|...|...:.:.|:.|.|.|....|||
Zfish   507 SFYTGQNLKKHQRIHTGEKPYKCSYCERGFSQLDPMKAHERIHTGEKPYECSHCSKRFNELHNLK 571

  Fly   846 KHTELHLAVKKYKCGTCGKRFAQFASLRWH------KKREHS 881
            .|..:|...|.|.|..|||.|||.::|:.|      |...||
Zfish   572 MHERIHTGEKPYTCDLCGKAFAQLSNLKKHTSAHEEKNCTHS 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rgrNP_001163089.2 MADF_DNA_bdg 335..420 CDD:287510 10/84 (12%)
MADF_DNA_bdg 465..551 CDD:287510 16/87 (18%)
MADF_DNA_bdg 595..682 CDD:287510 8/88 (9%)
C2H2 Zn finger 691..711 CDD:275368 5/19 (26%)
C2H2 Zn finger 719..739 CDD:275368 8/19 (42%)
zf-H2C2_2 731..756 CDD:290200 12/24 (50%)
COG5048 742..>824 CDD:227381 27/81 (33%)
C2H2 Zn finger 747..767 CDD:275368 6/19 (32%)
zf-H2C2_2 763..784 CDD:290200 10/20 (50%)
C2H2 Zn finger 775..795 CDD:275368 9/19 (47%)
C2H2 Zn finger 803..818 CDD:275368 4/14 (29%)
C2H2 Zn finger 831..851 CDD:275368 8/19 (42%)
C2H2 Zn finger 859..877 CDD:275368 9/23 (39%)
si:dkey-34m19.3XP_002662346.1 THAP 16..96 CDD:283206 14/62 (23%)
C2H2 Zn finger 389..409 CDD:275368 4/19 (21%)
zf-H2C2_2 401..426 CDD:290200 8/69 (12%)
C2H2 Zn finger 417..437 CDD:275368 5/19 (26%)
zf-H2C2_2 431..454 CDD:290200 9/22 (41%)
C2H2 Zn finger 445..465 CDD:275368 8/19 (42%)
zf-H2C2_2 457..482 CDD:290200 12/24 (50%)
C2H2 Zn finger 473..493 CDD:275368 6/19 (32%)
zf-H2C2_2 485..510 CDD:290200 10/24 (42%)
C2H2 Zn finger 501..521 CDD:275368 9/19 (47%)
zf-H2C2_2 513..538 CDD:290200 7/24 (29%)
C2H2 Zn finger 529..549 CDD:275368 5/19 (26%)
zf-H2C2_2 542..565 CDD:290200 5/22 (23%)
C2H2 Zn finger 557..577 CDD:275368 8/19 (42%)
zf-H2C2_2 569..594 CDD:290200 12/24 (50%)
C2H2 Zn finger 585..605 CDD:275368 9/19 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
00.000

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