DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lnpk and lnpk

DIOPT Version :9

Sequence 1:	NP_001286201.1	Gene:	Lnpk / 35842	FlyBaseID:	FBgn0033309	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001016474.1	Gene:	lnpk / 549228	XenbaseID:	XB-GENE-972741	Length:	423	Species:	Xenopus tropicalis

Alignment Length:	449	Identity:	142/449 - (31%)
Similarity:	210/449 - (46%)	Gaps:	106/449 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGFVLSKLRKEKSTEAVLEGLQTQIQALEKYMINTEERKRRFVTNFVGFTIGAYIVGFGLWWYFY 65
            ||.:|:|.|.:.||..|||.::..||:||::....::.::.:|.....::...||:.....:.:|
Frog     1 MGALLAKWRAKPSTVEVLEKMEKDIQSLEEFRDKNQKLRKIWVARLFFYSTILYILTSLTVYLWY 65

  Fly    66 FPPTMQECFMYLVPLLLFPIVIIFLRRLFTWYFQRKLNKNGDKLTRLKEDKRKILEQVMDKETYK 130
            .|..|....:.::..|.||::|.|:|.|...:|.|:..:|.|.|..||.:|:||||:||:|||||
Frog    66 LPDGMTARLLTMLLFLSFPVLIWFVRTLLILWFSRRTERNNDALELLKTEKKKILEEVMEKETYK 130

  Fly   131 VAVNLLERFG-DKKQLRISGLPTGSTPNRPQVERSPLTVAAVARTSSAGGQQQQQRSLAPYTSVY 194
            .|..:||||. |.::::...||....|..|:                 .||..:||     |:..
Frog   131 AAKLILERFDPDSRKIKELELPVPGPPITPR-----------------PGQDLRQR-----TAAQ 173

  Fly   195 RN-------NNNNQNTSLNSSVISTHSLGQMTSA--SPQLRAVQE------LRRR--SPFPIVD- 241
            ||       |...::..:...:.:|.||.:.|||  .|..|:||.      |:||  ||...|.
Frog   174 RNISVSTPVNPGQESPQVPGLLAATPSLQRDTSAPGGPPERSVQPTPQSNILQRRPGSPATTVSG 238

  Fly   242 ---------------DRSRSAIDRIVDFIVGDSPKDRFGMICKACHAHNGMLPKEEYEYTTFRCA 291
                           .|.|.|:||:::::|||.|::|:.:||:.|.:||||..|||:||..||||
Frog   239 MAIHPPGPPLARPILPRERGAMDRVIEYLVGDGPQNRYALICQQCFSHNGMALKEEFEYVAFRCA 303

  Fly   292 FCNVLNPARKKRPVAPRLSLEAPSDTANKRNDSSES----------------------------- 327
            :|..||||||.||.||||. |...|...:|.||..|
Frog   304 YCYFLNPARKTRPQAPRLQ-EINFDRQRQRTDSQGSVSSVQPPAAEQLENPQSPEAMEEDSPAQA 367

  Fly   328 ----------------ESSDDDSDKEPSARRALLQKLPS-GGADMDATAETEDLAMETE 369
                            |.:.|||:|:||   .:.:..|| ......|..|||:..||||
Frog   368 EEQAIEEDSTCSEQQWEEAPDDSEKDPS---PVAELNPSESNPSPPAANETEESFMETE 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lnpk	NP_001286201.1	zinc_ribbon_10	247..297	CDD:287076	25/49 (51%)
lnpk	NP_001016474.1	PTZ00449	<143..410	CDD:185628	82/292 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..169		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..247		15/46 (33%)
		zinc_ribbon_10	259..309	CDD:401882	25/49 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..423		25/108 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7014
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12319
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3752
OMA	1	1.010	-	-		QHG55649
OrthoDB	1	1.010	-	-		D1595535at2759
OrthoFinder	1	1.000	-	-		FOG0003331
OrthoInspector	1	1.000	-	-		oto105163
Panther	1	1.100	-	-	LDO	PTHR22166
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8618
SonicParanoid	1	1.000	-	-		X3815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110