Protein Alignment CG8736 and SUPT5H

DIOPT Version :10

• Sequence 1: NP_610394.2
• Gene: CG8736 / 35841
• FlyBaseID: FBgn0033308
• Length: 163
• Species: Drosophila melanogaster
• Sequence 2: NP_003160.2
• Gene: SUPT5H / 6829
• HGNCID: 11469
• Length: 1087
• Species: Homo sapiens
• Alignment Length: 168
• Identity: 47/168 - (27%)
• Similarity: 61/168 - (36%)
• Gaps: 39/168 - (23%)

  Fly    18 PQHQPAAQYPA--GVNPQDCPNFP---------ICDNARLHNPQPQWGAPQPQW-------NPQP 64
            |.|. .::.||  |....:.||.|         ..|:....:||...|.|.||.       :||.
Human   807 PLHD-GSRTPAQSGAWDPNNPNTPSRAEEEYEYAFDDEPTPSPQAYGGTPNPQTPGYPDPSSPQV 870

  Fly    65 QPQWNPQP-------QWQQPQPQWNPQPQPQWQAQPSWNAAPAAAPGGDKY-----PAGVNPQTC 117
            .||:|||.       ...|..|...|.||..:|..||..:....||....|     ||..:|...
Human   871 NPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPS 935

  Fly   118 PNYPYCDVNAGHAGAPVAAPPL-PGWTERLYPAGVSPH 154
            |    ....|..:.:||...|: ||...   |.|.:||
Human   936 P----MAYQASPSPSPVGYSPMTPGAPS---PGGYNPH 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8736	NP_610394.2	CPCFC	108..124	CDD:375060	5/20 (25%)
SUPT5H	NP_003160.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..92
		Spt5_N	<93..172	CDD:463406
		Interaction with SUPT4H1	176..270
		NGN_Euk	178..265	CDD:193577
		KOW_Spt5_1	276..313	CDD:240505
		Interaction with RNA polymerase II	313..420
		UBR5-degron. /evidence=ECO:0000269|PubMed:37478862	328..334
		KOW_Spt5_2	420..470	CDD:240506
		KOW_Spt5_3	471..521	CDD:240507
		KOW_Spt5_4	597..639	CDD:240508
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	670..700
		KOW_Spt5_5	702..751	CDD:240509
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	747..978		47/168 (28%)
		9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ], motif CTR1	754..817		3/10 (30%)
		CTD	772..889	CDD:215026	22/82 (27%)
		PHA03269	825..>970	CDD:165527	42/149 (28%)
		10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y, motif CTR2	844..950		31/109 (28%)
		KOW_Spt5_6	1028..1084	CDD:240510