Protein Alignment Cyp6a13 and ERG11

DIOPT Version :10

• Sequence 1: NP_610390.1
• Gene: Cyp6a13 / 35837
• FlyBaseID: FBgn0033304
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 529
• Identity: 129/529 - (24%)
• Similarity: 217/529 - (41%)
• Gaps: 106/529 - (20%)

  Fly     5 LVLVFTVGLLLYV----KLRWHYSYWSRRGVAGERP--VYFRGNMSGLGRDLHWTD----INLRI 59
            |.|...:.|::.:    .:.|...|..|:    :||  |::.         :.|..    ..::.
Yeast    25 LPLAQRISLIIIIPFIYNIVWQLLYSLRK----DRPPLVFYW---------IPWVGSAVVYGMKP 76

  Fly    60 YRKFRGVE-RYCGYFTF------MTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNL 117
            |..|...: :|...|:|      ||..|.....|.:.:..:.|.|  |:....|  ...|:.|..
Yeast    77 YEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVS--AEAAYAH--LTTPVFGKG 137

  Fly   118 LFLDGPEWRWLRQNLTQVFTSGKM-KFMFPNMV-----EVGEKLTQACRLQVGEIEAKDLCARFT 176
            :..|.|..|.:.|   :.|..|.: |..|.:.|     ||.:....:...::.|....      |
Yeast   138 VIYDCPNSRLMEQ---KKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTG------T 193

  Fly   177 TDVIGSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELAR----------KLR 231
            .||:           :..||.......||:..:.:.:.|...|.:...:|.:          .|.
Yeast   194 IDVM-----------VTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLP 247

  Fly   232 FRLFRPE------VSEFFLDTVRQTLDYRRREN-IHRNDLIQLLMELG--EEGVKDALSFEQIAA 287
            ...:|..      :|..::..:::    ||:.| |...|||..||:..  ::|||  ::.::||.
Yeast   248 LEHYRKRDHAQKAISGTYMSLIKE----RRKNNDIQDRDLIDSLMKNSTYKDGVK--MTDQEIAN 306

  Fly   288 QALVFFLAGFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVA 352
            ..:...:.|..||:.|.::.|..||..||||:.|..|.:.||....::||||.:||||.|:|.:.
Yeast   307 LLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIK 371

  Fly   353 ETLRKYPILPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEP--- 414
            ||||.:..|..|.|:..|:..:||::.::..|..:::.....|...|.:|:..:|:..|:..
Yeast   372 ETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSA 436

  Fly   415 ------EEIKARHPFA---------YLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSE-K 463
                  ||:.  :.|.         |||||.|...||||.|...|:.|.:...:|..|:...| |
Yeast   437 SSYSVGEEVD--YGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGK 499

  Fly   464 TQIPLKFSS 472
            |..|..|:|
Yeast   500 TVPPPDFTS 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	CYP6-like	67..484	CDD:410679	117/457 (26%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	117/458 (26%)