DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a13 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	509	Identity:	163/509 - (32%)
Similarity:	280/509 - (55%)	Gaps:	43/509 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTD----INLRIYRKFRGV 66
            ||:.|..:..|:...:.:..:.:.|:.|.:|:...||:      :::.|    .:...|:|:
Mouse    13 VLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGNI------INYLDGMWKFDDDCYKKY--- 68

  Fly    67 ERYCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLRQ 130
            .:..|::......|.|||.|:|:.::::: :|.|.:|..|..|  ..|..::...:..||:.||.
Mouse    69 GKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRPFGPV--GFLKKSITISEDEEWKRLRT 131

  Fly   131 NLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGE---IEAKDLCARFTTDVIGSCAFGLECNSL 192
            .|:..|||.|:|.|||.|.:.|:.|.:..|.:..:   |..||:...::.|||...:.|:..:||
Mouse   132 LLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKEEPINMKDIFGAYSMDVITGTSCGVNIDSL 196

  Fly   193 QDPESQFRRMGRSVTQ----EP-LHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQ--- 249
            .:|:..|.:..:.:.:    :| |.||::  |.|..| :...|...:|..:...||...|::
Mouse   197 NNPQDPFVQKIKKILKFKFFDPFLLSVVL--FPFLTP-IYEMLNLSIFPRQSMNFFKKFVKKMKK 258

  Fly   250 -TLDYRRRENIHRNDLIQLLMEL----GEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLY 309
             .|||.::   :|.|.:||:|..    |:|.:| |||..::|||.|:|...|:|.:||::||.:|
Mouse   259 DRLDYNQK---NRVDFLQLMMNTQNSKGQESLK-ALSDLEMAAQTLIFIFGGYDGTSTSISFIMY 319

  Fly   310 ELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQI 374
            |||.:||||::|:.|:...|. |...:|||::.:|.|||.||.|:||.||::..:.|.|.|:.:|
Mouse   320 ELATHPDVQKKLQDEIDRALP-NKAPVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEI 383

  Fly   375 PNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGER 439
              ..:.:..|:.::||::.:|.|||.:|:||.|.|.||..|......|:.|:|||.|||||||.|
Mouse   384 --HGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMPFGNGPRNCIGMR 446

  Fly   440 FGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRMEGLERP 493
            |..:.||:.:..:|::|.....|:||||:|. ||..:...::.:.|:....::|
Mouse   447 FALISVKLAVTGVLQNFTVQPCEETQIPVKI-SRQPIFRPEKPIILKFVSRDKP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	156/463 (34%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	157/475 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720