DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a13 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	171/510 - (33%)
Similarity:	269/510 - (52%)	Gaps:	58/510 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGVER 68
            :|||.:..|      .|.| ..:.::|:.|.:|:.|.|.:....|.| | ..::..|:|   ..:
  Rat    18 ILVLFYRFG------TRTH-GIFKKQGIPGPKPLPFLGTVLNYYRGL-W-KFDMECYKK---CGK 70

  Fly    69 YCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADRGLFHNVRDDP---LTGNLLFLDGPEWRWLR 129
            ..|.|...|....|||.|:|:.::::: ||.|.:|   .|:  .|   ::.::......||:..|
  Rat    71 IWGLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNR---RNI--GPVGIMSKSISVAKDEEWKRYR 130

  Fly   130 QNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGE---IEAKDLCARFTTDVIGSCAFGLECNS 191
            ..|:..||||::|.|||.:...|:.|.:..:.:|.:   :..|::...::.|||.|.:|.:..||
  Rat   131 AFLSPTFTSGRLKEMFPIIEHYGDILVKYLKQKVEKGKPLAMKEVFGAYSMDVITSTSFEVNINS 195

  Fly   192 LQDPESQF----RRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTV---RQ 249
            :.:|:..|    ::..|....:||. :.|..|.|..| :...|...||..:...||...|   :|
  Rat   196 INNPKDPFVEKVKKFQRFDFFDPLF-LSVVLFPFLTP-IYEMLNICLFPKDSVAFFQKFVYRMKQ 258

  Fly   250 T-LDYRRRENIHRNDLIQLLMELGEEGVKD-----ALSFEQIAAQALVFFLAGFDTSSTTMSFCL 308
            | ||.:.:   ||.|.:||:|. .....||     |||..:|.|||::|..|.::|:|:|:||.|
  Rat   259 TRLDSKHK---HRVDFLQLMMN-AHNNSKDKVSHKALSDIEIVAQAIIFIFASYETTSSTLSFVL 319

  Fly   309 YELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQ 373
            |.||.:||.|::|:.|:...|. |....|||:|.||.|||.|:.||.|.|||...|.|...|:.:
  Rat   320 YSLATHPDSQKKLQEEIDRALP-NKAPPTYDTVMEMEYLDMVLNETPRLYPIGYRLERVCKKDIK 383

  Fly   374 IPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGE 438
            :  ..:.:..||.::||.:::.|||:.:|:||:|.|.||..|...:..|:.|||||.|||||||.
  Rat   384 L--DGVFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKENKGSIDPYVYLPFGNGPRNCIGM 446

  Fly   439 RFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRMEGLERP 493
            ||..:.:|:.|..:|::|.|...|:||||||.|.:            |:.|.|:|
  Rat   447 RFALMNMKLALTKVLQNFSFQLCEETQIPLKLSRQ------------RLFGPEKP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	160/462 (35%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	156/452 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010