DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a13 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	178/521 - (34%)
Similarity:	294/521 - (56%)	Gaps:	48/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLG---RDLHW---TDINLRI 59
            |.:|::|..|:..|.:..|:.||.||.|||...|:       .||:.   .|..|   ..:.|.|
  Fly     1 MFSLILLAVTLLTLAWFYLKRHYEYWERRGFPFEK-------HSGIPFGCLDSVWRQEKSMGLAI 58

  Fly    60 YRKF-RGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFLDGP 123
            |..: :..||..|.:.....::.|.|.:|.|.::.:||:||.|||::.:...|||:.|:..|.|.
  Fly    59 YDVYVKSKERVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLRGQ 123

  Fly   124 EWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQV-----GEIEAKDLCARFTTDVIGSC 183
            .||.:|..|:..|||||:|.||....::|:|:....:.::     .|::.|.:...:..|:|.|.
  Fly   124 SWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIAST 188

  Fly   184 AFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRL-FRPEVSEFFLDTV 247
            .|||:.||.::|:::||::..........:.:....:|..|.:|:.| ||: |:..|....|..|
  Fly   189 IFGLDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFL-FRIGFKNPVGLAMLQIV 252

  Fly   248 RQTLDYRRRENIHRNDLIQLLMELGEEGVKD------------------ALSFEQIAAQALVFFL 294
            ::|::||.:..|.|.||:|||::|...|..|                  .:|.|.|.|||.:|::
  Fly   253 KETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYI 317

  Fly   295 AGFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYP 359
            ||.:|:.:|.:|.:||||..|::.:||:.||...|.:|:.|:||||:.:|.:||..|.||:||||
  Fly   318 AGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQETIRKYP 382

  Fly   360 ILPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFA 424
            .||.|.|..|::|.:|::|.::..|:.::|.::.||||.|.:||||.:||.||. ||.:..:|.|
  Fly   383 GLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFS-EESRNYNPTA 446

  Fly   425 YLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFK---FSRSEKTQIPLKFSSRNFLISTQEGVHLR 486
            ::|||||||.||.:|.|::..|:.::.:|::|.   .||||     ::|.:....:..:.||.:|
  Fly   447 FMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSE-----IEFENSGIALIPKHGVRVR 506

  Fly   487 M 487
            :
  Fly   507 L 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	162/476 (34%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	156/448 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461192
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	1	0.950	-	0	Normalized mean entropy	S3516
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.850