Protein Alignment Cyp6a13 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_610390.1
• Gene: Cyp6a13 / 35837
• FlyBaseID: FBgn0033304
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 142/525 - (27%)
• Similarity: 239/525 - (45%)
• Gaps: 63/525 - (12%)

  Fly     4 LLVLVFTVGLLLYVKLRWHYSYWS---RRGVAGERPV--YFRGNMSGLGRDLHWTDINLRIYRKF 63
            ||:|:.....||...|.|.|:::.   |.....:.|.  :|.|:: ||   :|.::..| :|.:.
Human    20 LLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHL-GL---IHSSEEGL-LYTQS 79

  Fly    64 RGV---ERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFLDGPEW 125
            ...   :..|.:.......:.|.....|:.::....:......:|::.....|...||...|.:|
Human    80 LACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKW 144

  Fly   126 RWLRQNLTQVFTSGKMKFMFPNMVEVGEKLT---QACRLQVGEIEAK----DLCARFTTDVIGSC 183
            ...|:.||..|....:|   |.|....|.:.   ...:|...|..|:    :..:..|.|.:..|
Human   145 SRHRRMLTPAFHFNILK---PYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKC 206

  Fly   184 AFGLECNSLQDPE---SQFRRMGRSVTQEPLHSVLVQAFM-FAQPELARKLRFRLFRPEVSEFFL 244
            .|..:.:..:.|.   :....:...||:.....:|...|: :..|:   ..|||.....|.: |.
Human   207 VFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPD---GQRFRRACRLVHD-FT 267

  Fly   245 DTVRQTLDYRRRENIHR---NDLIQ-------------LLMELGEEGVKDALSFEQIAAQALVFF 293
            |.|.|    .||..:..   :|.:|             ||:...|:|.|  ||.|.|.|:|..|.
Human   268 DAVIQ----ERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKK--LSDEDIRAEADTFM 326

  Fly   294 LAGFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLK-RNNQKLTYDSVQEMPYLDQVVAETLRK 357
            ..|.||:::.:|:.||.||.:|:.|||.|.||..:|| |..:::.:|.:.::|:|...:.|:||.
Human   327 FEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRL 391

  Fly   358 YPILPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHP 422
            :|.:|.:.|..|::..:|:.. ::..|...:|.|...||:|.::||||.:||.||:|:.||.|.|
Human   392 HPPVPAVSRCCTQDIVLPDGR-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSP 455

  Fly   423 FAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKF--SRSEKTQIPLKFSSRNFLISTQEGVHL 485
            .|::||..|||||||:.|...::||.|...|..|:.  ..:|..:.|      ..::..:.|:.|
Human   456 LAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKP------ELVLRAEGGLWL 514

  Fly   486 RMEGL 490
            |:|.|
Human   515 RVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	CYP6-like	67..484	CDD:410679	121/446 (27%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	123/461 (27%)