DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a13 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	191/511 - (37%)
Similarity:	290/511 - (56%)	Gaps:	32/511 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDI----NLRIYRK 62
            :.||:|:.::.::.|:..|...|:|.|.||...||.    .:.|..|:.....:    .::.:.:
  Fly     1 MLLLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPF----PVVGCTREFLTAKVPFFEQIQKFHE 61

  Fly    63 FRGVER--YCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPL-TGNLLFLDGPE 124
            ..|.|.  :.|.:.....:|.|.|||||:.:||:.|..|.:|.|..:..:|.| ..||.|...|.
  Fly    62 APGFENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPG 126

  Fly   125 WRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQAC-RLQVG-EIEAKDLCARFTTDVIGSCAFGL 187
            ||.||..::.||||||:|.|:|.||::|:.|..:. ||..| |::.||||:|||||:|.:.|||:
  Fly   127 WRELRTKISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGTEVQVKDLCSRFTTDLIATIAFGV 191

  Fly   188 ECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQTLD 252
            |.|:|||.:|:|....|::....|...:..|.:|..|.||...|.:||..|.::|...:|...|.
  Fly   192 EANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMIPALASLARVKLFSRETTKFIRSSVNYVLK 256

  Fly   253 YRRRENIHRNDLIQLLMELGEEG------VKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYEL 311
            .|.|....|||||.:|:.|..|.      :...:..:.:.|||.||..|||:||::||:..||||
  Fly   257 ERERTGEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSASTMTMTLYEL 321

  Fly   312 ALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLR---------R 367
            |.|..:|:|||.|::... .:...::|:.:||||||.|||.||||||||:.::.|         |
  Fly   322 AKNEALQDRLRQEIVDFF-GDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQPAEGER 385

  Fly   368 STKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGP 432
            .|.|   |..|:.|..|..|.:...::|.||:.:|||||:||.||........:..||:|||.||
  Fly   386 FTLE---PFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNLNMDAYMPFGVGP 447

  Fly   433 RNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRME 488
            |||||.|.|.||.|:|||::||:.:|...:||...::::..:.:::::..:.||:|
  Fly   448 RNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEWAPTSPVMASKRDIILRVE 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	178/466 (38%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	178/474 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461132
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800