DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a13 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	142/504 - (28%)
Similarity:	243/504 - (48%)	Gaps:	34/504 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGL---GRDLHWTDINLRIYRKFR 64
            |.|.::..:..|:||.|.|::|||.:||:...:...|.|:...:   .|::.: ||: .||.:::
  Fly     6 TALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVY-DID-EIYEQYK 68

  Fly    65 GVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGL--FHNVRDDPLTGNLLF-LDGPEWR 126
            ..:...|.|......|.:...|....|.:.||.||.|..:  |.:.:.||:..|..| |.|..|:
  Fly    69 NTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWK 133

  Fly   127 WLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQ-----VGEIEAKDLCARFTTDVIGSCAFG 186
            ..|..:|...::.::|..:|..:.|.:|..:..|.|     ...:.|||||..:||:||..|..|
  Fly   134 ERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLG 198

  Fly   187 LECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQTL 251
            :...|..|..:....|.:.|.::....:.........|.:.:.....||..:|:.||.|.:::.:
  Fly   199 ISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLMQKCI 263

  Fly   252 DYRRRENI--HRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYELALN 314
            ..||....  .|:|.:..:::|.|   |..|:..::.:..:.|...||:|::..::..|..||.|
  Fly   264 QVRRESPAAQQRDDFLNYMLQLQE---KKGLNAAELTSHTMTFLTDGFETTAQVLTHTLLFLARN 325

  Fly   315 PDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRS--TKEYQIPNS 377
            |..|.:||.|:      ...:||::.:.|:|:.:..:.||||.:.  |.|..|.  |:..::.|.
  Fly   326 PKEQMKLREEI------GTAELTFEQISELPFTEACIHETLRIFS--PVLAARKVVTEPCELTNK 382

  Fly   378 NLI---LEPGSKIIIPVHSIHHDPELYPDPEKFDPSRF---EPEEIKARHPFAYLPFGEGPRNCI 436
            |.:   |.||..:||||:::||||:.|.:|:.|.|.||   .....|.|....:..||:|||.|.
  Fly   383 NGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRICP 447

  Fly   437 GERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHL 485
            |.||...|:|..||.::|:|....:.||:...:.....|:.:.:.||.|
  Fly   448 GMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMPALKGGVWL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	126/463 (27%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	126/454 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460952
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900