DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a13 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	182/516 - (35%)
Similarity:	271/516 - (52%)	Gaps:	40/516 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTLLVLVFTVGLLLYVKLRW-----HYSYWSRRGVAGERPVYFRGNMSGLGRD-LHWTDINLRIY 60
            |.||.:|...|.||.|.:.|     |:.:|.|.||.......|.||:..|.|. ..:.|....:|
  Fly    17 LVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRELY 81

  Fly    61 RKFRGVER-YCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPL-----TGNLLF 119
            .......| :.|.......:|.:.|..||:.||:.||:.|:.|  |...  ||.     :.||.|
  Fly    82 ESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSR--FETT--DPTCDTMGSQNLFF 142

  Fly   120 LDGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVG-----EIEAKDLCARFTTDV 179
            .....||...:.....|.:||::.|:..:..:|:||.:....::.     |:|.|.|||.||||:
  Fly   143 SKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDI 207

  Fly   180 IGSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAF-MFAQPELARKLRFRLFRPEVSEFF 243
            |.|.|||:|.:|||:||::||||...| .:|....|:..| ||..|.|:.::...|:..|...|
  Fly   208 IASLAFGIEAHSLQNPEAEFRRMCIEV-NDPRPKRLLHLFTMFFFPRLSHRVGTHLYSEEYERF- 270

  Fly   244 LDTVRQTLDY----RRRENIHRNDLIQLLMELGEEGVKDALSF--EQIAAQALVFFLAGFDTSST 302
               :|:::||    |.....:|:|||.:.::|......:::..  :..||||....||||||||:
  Fly   271 ---MRKSMDYVLSQRAESGENRHDLIDIFLQLKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSS 332

  Fly   303 TMSFCLYELALNPDVQERLRVEVLAVLKRN-NQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLR 366
            |::|.|||||.|..:|:|||.|:.|.|:.: :::|:.|:|..:.||.|||.|.||.||....|.|
  Fly   333 TITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDR 397

  Fly   367 --RSTKEYQIP----NSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAY 425
              .|...|.:.    .|...|..|:.:.|.|..||.|.:.:|:||.|||.||..|:.:..||..|
  Fly   398 CCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTY 462

  Fly   426 LPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLR 486
            ||||.|||.|||...|:|::||||:::|..|:....|:|...::|..:.|:::...|.:||
  Fly   463 LPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVLTAHNGTYLR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	164/468 (35%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	157/432 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461072
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900