DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a13 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	517	Identity:	154/517 - (29%)
Similarity:	267/517 - (51%)	Gaps:	64/517 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINL-RIYRKFRGV 66
            ||:|||.|: ||:|..  |.:.::.:.|:.|.||:.|.|......:.:...||.. :.|.|..|:
Zfish    12 TLVVLVITL-LLIYGV--WPHGFFKKLGIPGPRPLPFVGTALSYSKGICNFDIECSKKYGKVWGI 73

  Fly    67 ERYCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADRGLFHNVRDD---PLTGNLLFLDGPEWRW 127
              |.|....    |.:.|||:|:.|:::| :|:|.:|   .|:..|   |....:..:....||.
Zfish    74 --YDGRLPL----LLVTDLEMIKTILVKDCYSTFTNR---RNMNPDLVGPFADGITLVKDERWRR 129

  Fly   128 LRQNLTQVFTSGKMKFMFP-----------NMVEVGEKLTQACRLQVGEIEAKDLCARFTTDVIG 181
            :|.:|:..||||::|.:||           ||.:....|         .::.||:.|.::.||:.
Zfish   130 IRSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKDPNL---------PLKIKDVVAPYSLDVVA 185

  Fly   182 SCAFGLECNSLQDPESQFRRMGRSVTQ-EPLHSV-LVQAFMFAQPELARKLRFRLFRPEVSEFFL 244
            |.:|.::.:|:.:|:..|....:|... .||..: |:.||..:...|..|:...:|....::|:.
Zfish   186 SSSFSVDFDSINNPDDPFVTSIKSFFNINPLSPLFLLLAFCPSAANLLAKMGISVFSRSTTDFYY 250

  Fly   245 DTVRQTLDYRRRENIHRNDLIQLLM--ELGEEGVKD--------ALSFEQIAAQALVFFLAGFDT 299
            ..:|:..|.....| .|.|.::|::  ::.::.|||        .|:..:|.:|:.:|.|.|::|
Zfish   251 KALRKIKDEHNESN-GRVDFLKLMIQNQIPDDQVKDTASEQPVKGLTDHEILSQSFIFILGGYET 314

  Fly   300 SSTTMSFCLYELALNPDVQERLRVEVLAVLKRN---NQKLTYDSVQEMPYLDQVVAETLRKYPIL 361
            :|||:|:.||.||.|||..|:|..|:    .:|   :..:|||::..|.||:..:.|::|.:|..
Zfish   315 TSTTLSYLLYNLATNPDCLEKLVEEI----DKNFPLDIPITYDALMRMDYLEMAIHESMRVFPAG 375

  Fly   362 PHLLRRSTKEYQIPNSNLILEPGSKII-IPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAY 425
            |.|.|...|..:|   |.|..|.:.:: ||::.:..||:|:..|.:|.|.||.||.....:..|:
Zfish   376 PRLERVCKKTVEI---NGITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKTEINQCAF 437

  Fly   426 LPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRM 487
            :|||.|||||||.||..:.:|:.:|.||:.:.....::||||::.   ||....:..:.|::
Zfish   438 MPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQL---NFFFQPKVPITLKL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	141/474 (30%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	143/486 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.720