DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a13 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	167/490 - (34%)
Similarity:	271/490 - (55%)	Gaps:	48/490 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGVERYC 70
            ||:.|..:|.|:...:.:..:.:.|:.|.:||...|.:...|..:...|.:  .|:|:   .:..
  Rat    13 VLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGTIFNYGDGMWKFDDD--CYKKY---GKIW 72

  Fly    71 GYFTFMTKSLFIMDLELIRDIMIRD-FSSFADRGLFHNVRDDPLTGNLLFL-------DGPEWRW 127
            |::......|.|||.|:|:.::::: :|.|.:|..|         |.:.|:       :..||:.
  Rat    73 GFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCF---------GPMGFMKKAITMSEDEEWKR 128

  Fly   128 LRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQ--VGE-IEAKDLCARFTTDVIGSCAFGLEC 189
            ||..|:..|||||:|.|||.|.:.|:.|.:..|.:  .|| |..||:...::.|||...:||:..
  Rat   129 LRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGEPINMKDIFGAYSMDVITGTSFGVNV 193

  Fly   190 NSLQDPESQFRRMGRSVTQ----EP-LHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTV-- 247
            :||.:|:..|.:..:.:.:    :| |.||::  |.|..| :...|.|.:|..:...||...|
  Rat   194 DSLNNPQDPFVQKAKKILKFQIFDPFLLSVVL--FPFLTP-IYEMLNFSIFPRQSMNFFKKFVKT 255

  Fly   248 --RQTLDYRRRENIHRNDLIQLLMEL----GEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSF 306
              :..||..::..:   |.:||:|..    |:|..| |||..::||||::|...|:|.:||::||
  Rat   256 MKKNRLDSNQKSRV---DFLQLMMNTQNSKGQESQK-ALSDLEMAAQAIIFIFGGYDATSTSISF 316

  Fly   307 CLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKE 371
            .:||||..|:||::|:.|:...|. |...:|||::.||.|||.||.|:||.|||...|.|.|.|:
  Rat   317 IMYELATRPNVQKKLQNEIDRALP-NKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKD 380

  Fly   372 YQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCI 436
            .:|  :.:.:..|:.:.||::.:|.:||.:.:||:|:|.||..|...:..|:.|||||.||||||
  Rat   381 VEI--NGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFGNGPRNCI 443

  Fly   437 GERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFS 471
            |.||..:.:|:.::.:|::|.....||||||||.|
  Rat   444 GMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKIS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	161/463 (35%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	154/434 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770