Protein Alignment Cyp6a13 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_610390.1
• Gene: Cyp6a13 / 35837
• FlyBaseID: FBgn0033304
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 134/539 - (24%)
• Similarity: 228/539 - (42%)
• Gaps: 112/539 - (20%)

  Fly     1 MLTLLVLVFTVGLLLYVKLRW-------------HYSYWSRRGVAGERPVYFRGNMSGLGRDLHW 52
            :|.:.:|:|.| :.||.:.||             |:.|       |.:..|
Human    19 LLCMSLLLFQV-IRLYQRRRWMIRALHLFPAPPAHWFY-------GHKEFY-------------- 61

  Fly    53 TDINLRIYRKFRGVERY-C------GYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRD 110
            ......:|.|.  :|:| |      |.||..   ..:.|.:..:.::.|.....|   :.|.:.:
Human    62 PVKEFEVYHKL--MEKYPCAVPLWVGPFTMF---FSVHDPDYAKILLKRQDPKSA---VSHKILE 118

  Fly   111 DPLTGNLLFLDGPEWRWLRQNLTQVFTSGKMKFMFPNMVEV--------GEKLTQACRLQVGEIE 167
            ..:...|:.|||.:|:..||.:...|....:|.....|.|.        .|.:.|..||::.:
Human   119 SWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQ-- 181

  Fly   168 AKDLCARFTTDVIGSCAF----GLECNSLQDP--ESQF-------RRMGRSVTQEPLHSVLVQAF 219
               ..:..|.|.|..|||    .::.:|..|.  ::.|       :||...:.    |:.||..|
Human   182 ---HVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLH----HNDLVFKF 239

  Fly   220 MFAQPELARKLRFRLFRPEVSEF-----------FLDTVRQTLDYRRRENIHRNDLIQLLMELGE 273
            . :|.::     |..|..|:.:|           ..|.::|....:||.     |.:.:|:....
Human   240 S-SQGQI-----FSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRW-----DFLDILLSAKS 293

  Fly   274 EGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTY 338
            |..|| .|...:.|:...|..||.||:|:.:|:.||.||..|:.|:|.|.|:..:| .:...:|:
Human   294 ENTKD-FSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELL-GDGSSITW 356

  Fly   339 DSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPD 403
            :.:.:|||....:.|.||.|..:.::.|...|....|:.. .|..|..:.|.:.::||:|..:.|
Human   357 EHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGR-SLPAGITVFINIWALHHNPYFWED 420

  Fly   404 PEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFS--RSEKTQI 466
            |:.|:|.||..|..:..||:|::||..|.|||||:.|..::.||.:...|..||.:  .|...|
Human   421 PQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQ- 484

  Fly   467 PLKFSSRNFLISTQEGVHL 485
            |:    |..::.::.|:|:
Human   485 PV----RQVVLKSKNGIHV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	CYP6-like	67..484	CDD:410679	119/457 (26%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	122/470 (26%)