DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a13 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	166/499 - (33%)
Similarity:	272/499 - (54%)	Gaps:	47/499 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRK-FR 64
            |.|.|:||.:: :|||:.....:..:.:.|:.|.:|:.|.|              .:..||| |.
  Rat     9 METWLLLVISL-VLLYLYGTHSHGIFKKLGIPGPKPLPFLG--------------TILAYRKGFW 58

  Fly    65 GVERYC--------GYFTFMTKSLFIMDLELIRDIMIRD-FSSFADRGLFHNVRDDPLTGNLLFL 120
            ..::||        |.:......|.|.|.::|:.::::: :|:|.:|..|..|  ..|...:...
  Rat    59 EFDKYCHKKYGKLWGLYDGRQPVLAITDPDIIKTVLVKECYSTFTNRRNFGPV--GILKKAISIS 121

  Fly   121 DGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGEIEA-----KDLCARFTTDVI 180
            :..||:.:|..|:..|||||:|.|||.:.:..:.|.:  .::.|..|.     ||:...::.|||
  Rat   122 EDEEWKRIRALLSPTFTSGKLKEMFPIINQYTDMLVR--NMRQGSEEGKPTSMKDIFGAYSMDVI 184

  Fly   181 GSCAFGLECNSLQDPESQF----RRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSE 241
            .:.:||:..:||.:|:..|    :::.:....:||. :.|..|.|..| |...|...:|..:|.:
  Rat   185 TATSFGVNVDSLNNPQDPFVEKIKKLLKFDIFDPLF-LSVTLFPFLTP-LFEALNVSMFPRDVID 247

  Fly   242 FFLDTVRQTLDYRRRE-NIHRNDLIQLLMELGEEGVKD---ALSFEQIAAQALVFFLAGFDTSST 302
            ||..:|.:..:.|.:| ...|.|.:||::......|||   |||..:|.||:::|..||::|:|:
  Rat   248 FFKTSVERMKENRMKEKEKQRMDFLQLMINSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETTSS 312

  Fly   303 TMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRR 367
            .:||.||.||::||:|::|:.|:.|.|. |....|||::.:|.|||.||.||||.|||...|.|.
  Rat   313 ALSFVLYLLAIHPDIQKKLQDEIDAALP-NKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERV 376

  Fly   368 STKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGP 432
            ...:.:|  :.:.:..|:.::||..::|.||..:|:||:|.|.||..:.....:|:.|||||.||
  Rat   377 CKTDVEI--NGVFIPKGTVVMIPTFALHKDPHYWPEPEEFRPERFSKKNQDNINPYMYLPFGNGP 439

  Fly   433 RNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFL 476
            |||||.||..:.:||.||.:|::|.|...::||||||.|.:..|
  Rat   440 RNCIGMRFALMNMKVALVRVLQNFSFQPCKETQIPLKLSKQGLL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	156/465 (34%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	157/468 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770