Protein Alignment Cyp6a13 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_610390.1
• Gene: Cyp6a13 / 35837
• FlyBaseID: FBgn0033304
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 123/523 - (23%)
• Similarity: 213/523 - (40%)
• Gaps: 92/523 - (17%)

  Fly     2 LTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGE----RPVYFRGNMSGLGRD-LHWTDINLRIYR 61
            :.|:...||:.|:..::|...:......||...    .|:.|.|:....|:. :.:.:   ..|.
Human    35 MLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLE---NAYE 96

  Fly    62 KFRGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDD------------PLT 114
            |:..|..    ||.:.|:...:            ..|.|...||::..:|            |:.
Human    97 KYGPVFS----FTMVGKTFTYL------------LGSDAAALLFNSKNEDLNAEDVYSRLTTPVF 145

  Fly   115 GNLLFLDGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGEIEAKDLCARFTTDV 179
            |..:..|.|...:|.|.  ::..||.....|...|.:.||.|:......||...|::....:..:
Human   146 GKGVAYDVPNPVFLEQK--KMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELI 208

  Fly   180 I---GSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQ---------PELARKLRF 232
            |   ..|..|.|..|         ::...|.|  |::.|...|..|.         |...|  |.
Human   209 ILTASHCLHGKEIRS---------QLNEKVAQ--LYADLDGGFSHAAWLLPGWLPLPSFRR--RD 260

  Fly   233 RLFRPEVSEFFLDTVRQTLDYRRRENIHRNDLIQLLMELGEEGVKDA--LSFEQIAAQALVFFLA 295
            |..| |:.:.|...:::    ||:.....:|::|.|:   :...||.  |:.:::|...:...||
Human   261 RAHR-EIKDIFYKAIQK----RRQSQEKIDDILQTLL---DATYKDGRPLTDDEVAGMLIGLLLA 317

  Fly   296 GFDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPI 360
            |..|||||.::..:.||.:..:|::..:|...|...|...||||.::::..||:.:.||||..|.
Human   318 GQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPP 382

  Fly   361 LPHLLR-----RSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKAR 420
            :..::|     ::...|.||       ||.::.:.........:.:.:...|:|.|:..:...:.
Human   383 IMIMMRMARTPQTVAGYTIP-------PGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASG 440

  Fly   421 HPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNF--LISTQEGV 483
            ..|||:|||.|...||||.|..:|:|.....:||.::|.     .|...|.:.|:  :|.|.|..
Human   441 EKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFD-----LIDGYFPTVNYTTMIHTPENP 500

  Fly   484 HLR 486
            .:|
Human   501 VIR 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	CYP6-like	67..484	CDD:410679	108/449 (24%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	112/461 (24%)