DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a13 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	506	Identity:	159/506 - (31%)
Similarity:	274/506 - (54%)	Gaps:	43/506 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGVE 67
            |.|:|..::.||.....|.| ..:.|.|:.|..|:...||:....:.| | ..:...|:|:   .
Human    11 TWLLLAVSLVLLYLYGTRTH-GLFKRLGIPGPTPLPLLGNVLSYRQGL-W-KFDTECYKKY---G 69

  Fly    68 RYCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADR------GLFHNVRDDPLTGNLLFLDGPEW 125
            :..|.:......|.|.|.::||.::::: :|.|.:|      |...:.        :...:..||
Human    70 KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSA--------ISLAEDEEW 126

  Fly   126 RWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGE---IEAKDLCARFTTDVIGSCAFGL 187
            :.:|..|:..|||||:|.|||.:.:.|:.|.:..|.:..:   :..||:...::.|||...:||:
Human   127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGV 191

  Fly   188 ECNSLQDPESQFRRMGRSVTQ----EPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVR 248
            ..:||.:|:..|....:...:    :||...:: .|.|..| :...|...||..:...|...:|.
Human   192 NIDSLNNPQDPFVESTKKFLKFGFLDPLFLSII-LFPFLTP-VFEALNVSLFPKDTINFLSKSVN 254

  Fly   249 QTLDYRRRE-NIHRNDLIQLLMELGEEGVKD-----ALSFEQIAAQALVFFLAGFDTSSTTMSFC 307
            :....|..: ..||.|.:||:::  .:..|:     |||..::|||:::|..||::|:|:.:||.
Human   255 RMKKSRLNDKQKHRLDFLQLMID--SQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFT 317

  Fly   308 LYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEY 372
            |||||.:||||::|:.|:.|||. |....|||:|.:|.|||.||.||||.:|:...|.|...|:.
Human   318 LYELATHPDVQQKLQKEIDAVLP-NKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV 381

  Fly   373 QIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIG 437
            :|  :.:.:..||.::||.:::||||:.:.:||:|.|.||..:: .:..|:.|.|||.|||||||
Human   382 EI--NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK-DSIDPYIYTPFGTGPRNCIG 443

  Fly   438 ERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRME 488
            .||..:.:|:.|:.:|::|.|...::||||||..::. |:..::.:.|:::
Human   444 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG-LLQPEKPIVLKVD 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	148/462 (32%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	150/474 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720