Protein Alignment Cyp6a13 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_610390.1
• Gene: Cyp6a13 / 35837
• FlyBaseID: FBgn0033304
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 163/505 - (32%)
• Similarity: 274/505 - (54%)
• Gaps: 40/505 - (7%)

  Fly     3 TLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGVE 67
            |.|:|..::.||.....|.| ..:.:.|:.|..|:.|.||.... |..:|| .::..|:|:|.|
Human    11 TWLLLAVSLILLYLYGTRTH-GLFKKLGIPGPTPLPFLGNALSF-RKGYWT-FDMECYKKYRKV- 71

  Fly    68 RYCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADR------GLFHNVRDDPLTGNLLFLDGPEW 125
              .|.:......|.|.|.::|:.::::: :|.|.:|      |...|.        :...:..||
Human    72 --WGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNA--------ISIAEDEEW 126

  Fly   126 RWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACR--LQVGE-IEAKDLCARFTTDVIGSCAFGL 187
            :.:|..|:..|||||:|.|.|.:.:.|:.|.:..|  .:.|: :..|.:...::.|||.|.:||:
Human   127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV 191

  Fly   188 ECNSLQDPESQFRRMGRSVTQ-EPLHSVL--VQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQ 249
            ..:||.:|:..|....:.:.: .||...:  ::.|.|..| :...|...:|..:|..|...:|:|
Human   192 SIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTP-ILEALNITVFPRKVISFLTKSVKQ 255

  Fly   250 TLDYRRRE-NIHRNDLIQLLMELGEEGVKD-----ALSFEQIAAQALVFFLAGFDTSSTTMSFCL 308
            ..:.|.:| ..||.|.:||:::  .:..||     |||..::.||:::|..||::|:|:.:||.:
Human   256 IKEGRLKETQKHRVDFLQLMID--SQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFII 318

  Fly   309 YELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQ 373
            ||||.:||||::::.|:..||. |....|||:|.::.|||.||.||||.:|:...|.|...|:.:
Human   319 YELATHPDVQQKVQKEIDTVLP-NKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVE 382

  Fly   374 IPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGE 438
            |  :.:.:..|..::||.:.:||||:.:.:||||.|.||..:......|:.|.|||.|||||||.
Human   383 I--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGM 445

  Fly   439 RFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRME 488
            ||..:.:|:.||.:|::|.|...::||||||......|: |::.:.|:.|
Human   446 RFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLL-TEKPIVLKAE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	CYP6-like	67..484	CDD:410679	141/435 (32%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	144/442 (33%)