Protein Alignment Cyp6a13 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_610390.1
• Gene: Cyp6a13 / 35837
• FlyBaseID: FBgn0033304
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 119/456 - (26%)
• Similarity: 202/456 - (44%)
• Gaps: 69/456 - (15%)

  Fly    33 GERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGVERYCGYFTFMTKSLFIMDLELIRDIMI---- 93
            |..|.:::.:..| ||.|.  |:.|...:|:..|.|   ...|...|:.:...|.::..::
Human    44 GHLPCFWKKDEVG-GRVLQ--DVFLDWAKKYGPVVR---VNVFHKTSVIVTSPESVKKFLMSTKY 102

  Fly    94 -RDFSSFADRGLFHNVRDDPLTGNLLFLDG-------PEWRWLRQNLTQVFTSGKMKFMFPNMVE 150
             :|...:  |.|      ..:.|..||..|       ..|...|:.:...|:...:..:.....|
Human   103 NKDSKMY--RAL------QTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNE 159

  Fly   151 VGEKLTQACRLQV-GE--IEAKDLCARFTTDVIGSCAFGLECNSL---QDPESQFRRM---GRSV 206
            ..|:|.:....:. |:  :..:|:......|::...|||:|.:.|   |.|.||..::   |.:.
Human   160 KAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITA 224

  Fly   207 TQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEF--FLDTVRQTLDYRRRENIHRND------ 263
            ::..|...|        |...::||      ||.|.  ||..|.:....||||.:.|.:
Human   225 SRNTLAKFL--------PGKRKQLR------EVRESIRFLRQVGRDWVQRRREALKRGEEVPADI 275

  Fly   264 LIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYELALNPDVQERLRVEVLAV 328
            |.|:|.  .|||.:|.   |.:....:.||:||.:||:..::|.:.||:..|::..||:.||..|
Human   276 LTQILK--AEEGAQDD---EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEV 335

  Fly   329 LKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQIPNSNLILEPG-SKIIIPVH 392
            : .:.:.|.::.:..:.||.||:.|:||.||......|...:|..|..   :..|| :.::...:
Human   336 I-GSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG---VRVPGNTPLLFSTY 396

  Fly   393 SIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFK 457
            .:......:.||..|:|.||.|...|.|  |.|.||..|.|:|||::|.:::|||.:..||:..:
Human   397 VMGRMDTYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 459

  Fly   458 F 458
            |
Human   460 F 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	CYP6-like	67..484	CDD:410679	109/422 (26%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	113/438 (26%)