DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp6a13 and Cyp27a1

DIOPT Version :10

Sequence 1:NP_610390.1 Gene:Cyp6a13 / 35837 FlyBaseID:FBgn0033304 Length:493 Species:Drosophila melanogaster
Sequence 2:NP_077226.2 Gene:Cyp27a1 / 104086 MGIID:88594 Length:533 Species:Mus musculus


Alignment Length:505 Identity:119/505 - (23%)
Similarity:202/505 - (40%) Gaps:141/505 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 WTDINLRIYRKFRGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDP-LTG 115
            :|::||........|.|..|.:.             |||.|        |:...|  ||.. ||.
Mouse   105 YTNVNLASAPLLEQVMRQEGKYP-------------IRDHM--------DQWKDH--RDHKGLTY 146

  Fly   116 NLLFLDGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGEIEAKDLCARFT---T 177
            .:....|.:|..|||.|       |.:.:.|                       |..|.:|   .
Mouse   147 GIFIAQGEQWYHLRQAL-------KQRLLKP-----------------------DEAALYTDALN 181

  Fly   178 DVIGSCAFGLECNSLQDPESQFRRMGRSVTQEP-----LHSVLVQAFMFAQPELARKLRFRLFRP 237
            :||......|:         |.|....|..|.|     |:.:.::|..:    :..:.|....:|
Mouse   182 EVISDFITRLD---------QVRAESESGDQVPDMAHLLYHLALEAITY----ILFEKRIGCLKP 233

  Fly   238 EVSE-----------FFLDTV---------RQTLDYRRR-----ENIHR----------NDLIQL 267
            .:.|           .|.::|         |..|.:.:|     :||..          .:|...
Mouse   234 SIPEDTAAFIRSVAIMFQNSVYITFLPKWTRPLLPFWKRYLNGWDNIFSFGKKLIDEKVQELKAQ 298

  Fly   268 LMELGEEGVKDA------LSFEQIAAQALV-----FFLAGFDTSSTTMSFCLYELALNPDVQERL 321
            |.|.|.:||:.:      |:.|.::.|..:     ..|||.||:|.|:::.||.|:.:|::||.|
Mouse   299 LQETGPDGVRVSGYLHFLLTNELLSTQETIGTFPELLLAGVDTTSNTLTWALYHLSKSPEIQEAL 363

  Fly   322 RVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRST-KEYQIPNSNLILEPGS 385
            ..||..|:...... .:.....||.|..|:.||||.||::|...|..| ||.:|  :..:....:
Mouse   364 HKEVTGVVPFGKVP-QHKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEI--NGFLFPKNT 425

  Fly   386 KIIIPVHSIHHDPELYPDPEKFDPSRF----EPEEIKARHPFAYLPFGEGPRNCIGERFGKLQVK 446
            :.::..:.:..||.::|:|..|.|.|:    |.:.....|||..:|||.|.|:|:|.|..:|:::
Mouse   426 QFVLCHYVVSRDPSVFPEPNSFQPHRWLRKKEADNPGILHPFGSVPFGYGVRSCLGRRIAELEMQ 490

  Fly   447 VGLVYLLRDFKFSRSEKTQIP----LKFSSRNFLISTQEGVHLRMEGLER 492
            :.|..|::.::.:.:     |    :|..||..|:.:::   :|:..|:|
Mouse   491 LMLSRLVQKYEIALA-----PGMGEVKTVSRIVLVPSKK---VRLHFLQR 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp6a13NP_610390.1 CYP6-like 67..484 CDD:410679 112/480 (23%)
Cyp27a1NP_077226.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..60
cytochrome_P450 91..527 CDD:477761 116/498 (23%)
Sterol-binding. /evidence=ECO:0000255 386..400 7/13 (54%)
Blue background indicates that the domain is not in the aligned region.

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