Protein Alignment Cyp6a13 and CYP3A7-CYP3A51P

DIOPT Version :9

• Sequence 1: NP_610390.1
• Gene: Cyp6a13 / 35837
• FlyBaseID: FBgn0033304
• Length: 493
• Species: Drosophila melanogaster
• Sequence 2: NP_001243426.2
• Gene: CYP3A7-CYP3A51P / 100861540
• HGNCID: 51504
• Length: 535
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 163/505 - (32%)
• Similarity: 274/505 - (54%)
• Gaps: 40/505 - (7%)

  Fly     3 TLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRGVE 67
            |.|:|..::.||.....|.| ..:.:.|:.|..|:.|.||.... |..:|| .::..|:|:|.|
Human    11 TWLLLAVSLILLYLYGTRTH-GLFKKLGIPGPTPLPFLGNALSF-RKGYWT-FDMECYKKYRKV- 71

  Fly    68 RYCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADR------GLFHNVRDDPLTGNLLFLDGPEW 125
              .|.:......|.|.|.::|:.::::: :|.|.:|      |...|.        :...:..||
Human    72 --WGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNA--------ISIAEDEEW 126

  Fly   126 RWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACR--LQVGE-IEAKDLCARFTTDVIGSCAFGL 187
            :.:|..|:..|||||:|.|.|.:.:.|:.|.:..|  .:.|: :..|.:...::.|||.|.:||:
Human   127 KRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGV 191

  Fly   188 ECNSLQDPESQFRRMGRSVTQ-EPLHSVL--VQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQ 249
            ..:||.:|:..|....:.:.: .||...:  ::.|.|..| :...|...:|..:|..|...:|:|
Human   192 SIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTP-ILEALNITVFPRKVISFLTKSVKQ 255

  Fly   250 TLDYRRRE-NIHRNDLIQLLMELGEEGVKD-----ALSFEQIAAQALVFFLAGFDTSSTTMSFCL 308
            ..:.|.:| ..||.|.:||:::  .:..||     |||..::.||:::|..||::|:|:.:||.:
Human   256 IKEGRLKETQKHRVDFLQLMID--SQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFII 318

  Fly   309 YELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQ 373
            ||||.:||||::::.|:..||. |....|||:|.::.|||.||.||||.:|:...|.|...|:.:
Human   319 YELATHPDVQQKVQKEIDTVLP-NKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVE 382

  Fly   374 IPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGE 438
            |  :.:.:..|..::||.:.:||||:.:.:||||.|.||..:......|:.|.|||.|||||||.
Human   383 I--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGM 445

  Fly   439 RFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRME 488
            ||..:.:|:.||.:|::|.|...::||||||......|: |::.:.|:.|
Human   446 RFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLL-TEKPIVLKAE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	151/461 (33%)
CYP3A7-CYP3A51P	NP_001243426.2	p450	39..492	CDD:278495	153/472 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134304
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720