DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a13 and Cyp3a59

DIOPT Version :9

Sequence 1:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001098630.1	Gene:	Cyp3a59 / 100041449	MGIID:	3769707	Length:	503	Species:	Mus musculus

Alignment Length:	522	Identity:	163/522 - (31%)
Similarity:	279/522 - (53%)	Gaps:	69/522 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLVFTVGLLLYVKLRWHYSYWSRRGVAGERPV--------YFRGNMSGLGRDLHWTDINLRIYRK 62
            ||:.|..:..|:...:.:..:.:.|:.|.:|:        ||.| |.....|         .|:|
Mouse    13 VLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFDG-MWKFDED---------CYKK 67

  Fly    63 FRGVERYCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADRGLFHNVRDDPLTGNLLFL------ 120
            :   .:..|::......|.|||.|:|:.::::: :|.|.:|         |..|.:.||
Mouse    68 Y---GKIWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNR---------PTLGPVGFLKKSITI 120

  Fly   121 -DGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRL--QVGE-IEAKDLCARFTTDVIG 181
             :..||:.||..|:..|||||:|.|||.|.:.|:.|.:..|.  :.|| |..||:...::.|||.
Mouse   121 SEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSMDVIT 185

  Fly   182 SCAFGLECNSLQDPESQFRRMGRSVTQ----EP--LHSVLVQAFMFAQPELARKLRFRLFRPEVS 240
            ..:||:..:||.:|::.|.:..:.:.:    :|  |.::|   |.|..| :...|...:|..:..
Mouse   186 GTSFGVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLSTIL---FPFLTP-IYEMLNLSIFPRDSM 246

  Fly   241 EFFLDTVRQTLDYRRRENI-----HRNDLIQLLMEL----GEEGVKDALSFEQIAAQALVFFLAG 296
            .||...|::    .::|.:     :|.|.:||:|..    |:|..| |||..::||||::|...|
Mouse   247 NFFKKFVKR----MKKERLASKQKNRVDFLQLMMNTQNSKGQESQK-ALSDLEMAAQAVIFIFGG 306

  Fly   297 FDTSSTTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPIL 361
            :|.:||::|..:||||.:||||::|:.|:...|. |...:|||::.:|.|||.||.|:||.||..
Mouse   307 YDATSTSISLIMYELATHPDVQKKLQDEIDRTLP-NKAPVTYDALMDMEYLDMVVNESLRLYPTA 370

  Fly   362 PHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYL 426
            ..|.|.|.|:.:|  :.:.:..|:.::||::.:|.:||.:|:|::|.|.||..|......|:.|:
Mouse   371 IRLERVSKKDVEI--NGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYIYM 433

  Fly   427 PFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRMEGLE 491
            |||.|||||:..||..:.:|:.::.:|::|.....|:||||||. ||..:...::.:.|::...:
Mouse   434 PFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLKI-SREPVFQPEKPIILKVVSRD 497

  Fly   492 RP 493
            :|
Mouse   498 KP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	156/476 (33%)
Cyp3a59	NP_001098630.1	p450	39..493	CDD:278495	157/488 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3516
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.670