DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and CYP721A1

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_177649.1	Gene:	CYP721A1 / 843850	AraportID:	AT1G75130	Length:	505	Species:	Arabidopsis thaliana

Alignment Length:	494	Identity:	116/494 - (23%)
Similarity:	213/494 - (43%)	Gaps:	74/494 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PLPIVGNMRGIVKKY--HFRDINQRIYKKFKGQGPIAGMYMFFKRTALIT-DLDFIKQVMIKDFS 97
            |:|...|....|.:.  |:.:.: |:|.|       ..:|.|..:..:.| |...|::.:...
plant    64 PIPSGRNPHEFVHRVAPHYHEWS-RVYGK-------TFLYWFGSKPVVATSDPRLIREALTTG-- 118

  Fly    98 YFQDRGAFTNPRDDPLTGHLFA-----LEGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGD 157
                 |:|.....:||:..|:|     |.|::|...|......||..|:|:....:|...:.|.:
plant   119 -----GSFDRIGHNPLSKLLYAQGLPGLRGDQWAFHRRIAKQAFTMEKLKRWVPQMVTSTMMLME 178

  Fly   158 AMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGLECNSLQDPSA--EFRQKGREIFTRRRHS 220
            ..:......  ||..:|:.......:.:::...|||   ||:::...  |.:::...:|...|.|
plant   179 KWEDMRNGG--EEIELEVHKEMHNLSAEMLSRTAFG---NSVEEGKGIFELQERMMRLFYLVRWS 238

  Fly   221 TLVQSFIF----TNA---RLARKLRIKVLPDDLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIEL 278
            ..:..|.|    ||.   |:.:::|:.:|.      .:...|..|:   |:|.....|:......
plant   239 VYIPGFRFFPSKTNREIWRIEKQIRVSILK------LIENNKTAVE---KSGTLLQAFMSPYTNQ 294

  Fly   279 RAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEI 343
            ..::::             |.:|::..:...|:.|..||:::.|:..|..||:..:.|...|||:
plant   295 NGQEEK-------------LGIEEVTDECKTFYFAAKETTANLMTFVLVLLAMNQEWQNIAREEV 346

  Fly   344 ESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALI 408
            ..||...  |....|:|..:..|..:::||||.:|....|.|:|.|..::  .|:.:..|....:
plant   347 ICVLGQT--GLPTLDILQDLKTLSMIINETLRLYPPAMTLNRDTLKRAKL--GDLDIPAGTQLYL 407

  Fly   409 PVHNIHHDPEIY-PEPEKFDPSRF-DPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSL 471
            .|..:|||.|.: .:.|:|:|.|| ||:    :.....:|||.|||.|:|......:||..|.::
plant   408 SVVAMHHDKETWGDDAEEFNPRRFEDPK----KQSALLVPFGLGPRTCVGQNLAVNEAKTVLATI 468

  Fly   472 LRRFKFSVS-NRTDVPLIFSKKSFLLTTNDGIYLKVERV 509
            |:.:.|.:| :....|::|    ..|...:|.:|...|:
plant   469 LKYYSFRLSPSYAHAPVLF----VTLQPQNGAHLLFTRI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	115/489 (24%)
CYP721A1	NP_177649.1	p450	26..495	CDD:386267	113/484 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900