DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	527	Identity:	170/527 - (32%)
Similarity:	272/527 - (51%)	Gaps:	67/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGN----MRGIVKKYHF-RDINQR---IY 60
            |..||...|.|.|.........:|:.|:|..||||.:|.    :||:   ::| |:.|::   ::
Human    11 TWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGL---WNFDRECNEKYGEMW 72

  Fly    61 KKFKGQGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHL-----FAL 120
            ..::||.|:          .:|.|.|.||.|::|: .|    ..|||.......|.|     ||
Human    73 GLYEGQQPM----------LVIMDPDMIKTVLVKE-CY----SVFTNQMPLGPMGFLKSALSFA- 121

  Fly   121 EGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTD 185
            |.|||:.:|..|:|.|||.|.|:|..:|    .:.||.:.:::::......::.:||....:|.|
Human   122 EDEEWKRIRTLLSPAFTSVKFKEMVPII----SQCGDMLVRSLRQEAENSKSINLKDFFGAYTMD 182

  Fly   186 VIGSCAFGLECNSLQDPSAEFRQKGREI--------FTRRRHSTLVQSFIFTNARLARKLRIKVL 242
            ||....||:..:||.:|...|.:..:::        |.     .|:..|.|... :...|.|.:.
Human   183 VITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFL-----LLISLFPFLTP-VFEALNIGLF 241

  Fly   243 PDDLTQFFMSTVKNTVDYRLKNGIK-RNDFIEQMIELRAEDQEAAKKGQGIDLSH-GLTLEQMAA 305
            |.|:|.|..::::...:.|||:..| |.||.:|||     |.:.:|:.:    || .|:..::.|
Human   242 PKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMI-----DSQNSKETK----SHKALSDLELVA 297

  Fly   306 QAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVL 370
            |:.:...|.::|:|:|:...:||||..||:||:|:|||::||.|  ...:.||.|.||.|||.|:
Human   298 QSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPN--KAPVTYDALVQMEYLDMVV 360

  Fly   371 SETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDP-SRFDPE 434
            :||||..|::..:.|...||.:|  :.:.:.||:..::|::.:||||:.:.|||||.| |||..:
Human   361 NETLRLFPVVSRVTRVCKKDIEI--NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKK 423

  Fly   435 EVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTN 499
            ...:.....|:|||.|||||||:||.....|:.::..|:.|.|.....|.:||...... :|...
Human   424 NKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP-ILQPE 487

  Fly   500 DGIYLKV 506
            ..|.|||
Human   488 KPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	160/497 (32%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	160/497 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820