DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	496	Identity:	158/496 - (31%)
Similarity:	257/496 - (51%)	Gaps:	36/496 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKGQGPIAGMYMFFKRTALITDLDFIK 89
            |:|:.|:|....:|..|.|......:|..|::  .::|:   |.|.|:|...:....|.|...||
Zfish    28 YFKKLGIPGPKAIPFFGTMLRYKDGFHVFDMD--CFEKY---GRIWGIYDGRQPVLCIMDQTIIK 87

  Fly    90 QVMIKDFSYFQDRGAFTNPRDDPLTGHLF----ALEGEEWRAMRHKLTPVFTSGKIKQMSKVIVD 150
            .|:||: .|    ..|||.|:..|.|.|:    ..|.::||.:|..|:|.||||::|:|..::..
Zfish    88 TVLIKE-CY----SLFTNRRNFRLNGALYDAVSIAEDDDWRRIRSVLSPSFTSGRLKEMFGIMKK 147

  Fly   151 VGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGLECNSLQDPSAEFRQKGREI-- 213
            ....|.|:|.|..|..:    :.:||:....::.||:.|.||.::.:||.:|...|....:::
Zfish   148 HSHILVDSMGKTAKRGE----SADIKEFFGAYSMDVVTSTAFSVDIDSLNNPKDPFVTNIKKMLK 208

  Fly   214 FTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLTQFFMSTV------KNTVDYRLKNGIKRNDFI 272
            |.......|:.:|....|.:..|:...:.|..:|.||.:.:      ::|......|..||.||:
Zfish   209 FDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSDRDTKTVAKDNTKKRVDFL 273

  Fly   273 EQMIELRAEDQEAAK-KGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQ 336
            :.|:    :.|...| |..|.....||:..::.:|:.:|..||:||||||:|...|.||..|:..
Zfish   274 QLMV----DSQTGVKHKSDGEHTEKGLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETM 334

  Fly   337 QRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLD 401
            ::|:|||:....|  ...::|:.|..|.|||..|||:||..|:...|.|...|..:|  :.:::.
Zfish   335 KKLQEEIDETFPN--QAPVDYETLMSMDYLDAALSESLRLFPVAARLERVCKKTVEI--NGLLIP 395

  Fly   402 KGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKI 466
            |.::.::|.:.:|.||:.:.|||.|.|.||.....::..|..|:|||.|||||||:||.::..|:
Zfish   396 KDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKL 460

  Fly   467 GLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKVE 507
            .:|.:|:||..||.:.|.|||...... ||:..|.|.||::
Zfish   461 AIVEILQRFDVSVCDETQVPLELGFNG-LLSPKDPIKLKLQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	154/486 (32%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	154/486 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820