DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Cyp6d5

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	167/494 - (33%)
Similarity:	273/494 - (55%)	Gaps:	37/494 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVGVVLGLA----YSLHIK-IFSYWKRKGVPHETPLPI-VGNMRGIVKKYHFRDINQRIYKKFKG 65
            ::|:.|.:|    ..:::| .||||.|||.| .|.:.| .|.:..:.|..  |.....||..:|.
  Fly     1 MIGIYLLIAAVTLLYVYLKWTFSYWDRKGFP-STGVSIPFGALESVTKGK--RSFGMAIYDMYKS 62

  Fly    66 -QGPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFALEGEEWRAMR 129
             :.|:.|:|:..:...|:.|......|::|||:.|.|||.:.:.::||::..||.:||..|||:|
  Fly    63 TKEPVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSASLFQMEGASWRALR 127

  Fly   130 HKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGL 194
            :||||.|||||:|.|.:....||.:|.|::.|.:.....:|  :|:|.|.|.:..|:|.:..|||
  Fly   128 NKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKE--LELKKLMATYAIDIIATTIFGL 190

  Fly   195 ECNSLQDPSAEFRQKGREIFTRRRHSTLVQ---SFIFTNARLARKLRIKV-LPDDLTQFFMSTVK 255
            :.:|..||:.||:...::: .|.....:::   ||::..   ..|..:|: ...:.|:.......
  Fly   191 DVDSFADPNNEFQIISKKV-NRNNIEDIIRGTSSFLYPG---LEKFFVKIGWKQEATERMRELSN 251

  Fly   256 NTVDYRLKNGIKRNDFIEQMIELRAEDQ----------EAAKKGQGIDLSHGLTLEQMAAQAFVF 310
            .|||.|.:|.|.|.|.::.:::||.:.:          |:.|.|     ...::.:.:|.|.|:|
  Fly   252 RTVDLREQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNG-----VKSMSKDLIAGQLFLF 311

  Fly   311 FVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLR 375
            :|||:||::||.|..||||...|::.::.:|::.|.:.. .||:|.||.::.|.||:..:.||.|
  Fly   312 YVAGYETTASTTSFTLYELTQNPEVMEKAKEDVRSAIEK-HGGKLTYDAISDMKYLEACILETAR 375

  Fly   376 KHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRH 440
            |:|.||.|.|..||||.:|:|.:|:.||...:|.:..:|.|.|.:|:|..:.|.|: .|..|:..
  Fly   376 KYPALPLLNRICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERY-LENGKDYT 439

  Fly   441 PMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSV 479
            ..||||||:|||.|||.|.||:..||.:..:|..|...:
  Fly   440 QAAYLPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEI 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	156/464 (34%)
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	147/424 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	8.070