DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a14 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	178/523 - (34%)
Similarity:	273/523 - (52%)	Gaps:	39/523 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGI-VKKYHFRDINQRIY-----KKFK 64
            ||..:...|.|........::|.:|:.:|.|:...|||.|: ::|....||...:|     |||.
  Fly     7 ALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGGSKKFF 71

  Fly    65 GQGPIAGMYMFFKRTAL--ITDLDFIKQVMIKDFSYF-QDRGAF-TNPRDDP-----LTG-HLFA 119
            |        :|.:|..|  :.|.|.|||:.||||.:| ..|..| |:..|||     |.| .||:
  Fly    72 G--------IFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFS 128

  Fly   120 LEGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTT 184
            :....|:.||..|:|.||..|::||.:::..|.....|.:.:  .:::|:|..:::||.|.|||.
  Fly   129 MRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQ--DDSRVQENELDMKDYCTRFTN 191

  Fly   185 DVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQS----FIFTNARLARKLRIKVLPDD 245
            |||.|.||||:.||.:|....|.|.|:::.|    .|.:||    ..|....|.:.|::::....
  Fly   192 DVIASTAFGLQVNSFKDRENTFYQMGKKLTT----FTFLQSMKFMLFFALKGLNKILKVELFDRK 252

  Fly   246 LTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVF 310
            .||:|:..|.:.:.||.::.|.|.|.|..::|.|...|....|...:   ...:...:.||.|||
  Fly   253 STQYFVRLVLDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAV---REWSDRDIVAQCFVF 314

  Fly   311 FVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLR 375
            |.||||||:..|....:||....|:||||.||::.|..:::|.||.|:.:..|.|||||::|.||
  Fly   315 FFAGFETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLR 379

  Fly   376 KHPLLPHLIRETTKD--YQIPNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKN 438
            |.|....:.||..||  :.:....:.:.||.:..:|....|.||:.:..|.||||.||..|..::
  Fly   380 KWPAAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKES 444

  Fly   439 RHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIY 503
            ..|..|.|||.|.|||||.||..::||..:..||:.::|:.:.::.:||......|.|:...|.:
  Fly   445 IQPFTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFW 509

  Fly   504 LKV 506
            :|:
  Fly   510 IKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	171/495 (35%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	170/490 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
	10	10.000