DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a14 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	110/503 - (21%)
Similarity:	222/503 - (44%)	Gaps:	58/503 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLFTIALVGVVLGLAYSLHIKIFSYWKRK--GVPHETPLPIVGNMRGIVK--KYHFRDINQRIYK 61
            :||  .||.::.|..:.:|:..... :||  .:|.....|::|.|:.:::  ...|..:.:....
  Fly     2 LLF--LLVVLLFGAGWIIHLGQADR-RRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVL 63

  Fly    62 KFKGQGPIAGMYMFFKRTALITDLDFIKQVM-----IKDFSYFQDRGAFTNPRDDPLTGHLFALE 121
            ||   |.:..:::|.:...:..|.:..:|::     :.....::..|.:       |...|...:
  Fly    64 KF---GHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQW-------LGNGLLLSD 118

  Fly   122 GEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKD----LCARF 182
            |:.|...|..:||.|....::|..:|.        |.......:...::.|....|    :||.
  Fly   119 GKVWHQRRKIITPTFHFSILEQFVEVF--------DQQSNICVQRLAQKANGNTFDVYRSICAA- 174

  Fly   183 TTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIKVLPDDLT 247
            ..|:|...|.|.:..:..:.|..:.:...|       .|.:.|:.|.:..|..:|...:....|.
  Fly   175 ALDIIAETAMGTKIYAQANESTPYAEAVNE-------CTALLSWRFMSVYLQVELLFTLTHPHLK 232

  Fly   248 QFFMSTVKNTVDYRLKNGIKRNDFIE----QMIELRAEDQEAAKKGQGIDL-------SHGLTLE 301
            ......::...::.:|...||...:|    ::::...||..:.::...:|:       ...||.:
  Fly   233 WRQTQLIRTMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTND 297

  Fly   302 QMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYL 366
            ::..:...|...|.:|::|.:|.||:||:..|::|.::.|||..||.......::...|.::.|:
  Fly   298 EIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYM 362

  Fly   367 DQVLSETLRKHPLLPHLIRETTKDYQIPNS---DIVLDKGILALIPVHNIHHDPEIYPEPEKFDP 428
            :.|:.|:||.:|.:|.:.|:...|::..:|   |.|:..|...:|.:..:|..||.:|.|::|.|
  Fly   363 ECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIP 427

  Fly   429 SRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFK 476
            .|.  |......|...:||..|||||||.:|.:::.|:.|..::|.::
  Fly   428 ERH--ENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYE 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	102/470 (22%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	95/433 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840